cancer stem cells

[Acta Pharmacologica Sinica] Researchers found that QAP14 inhibited colony formation, cell motility, mammosphere formation and CSC frequency, induced CSC apoptosis and dopamine D1 receptor expression, and increased cAMP/cGMP levels.

[Scientific Reports] Scientists established liver tumor cell lines from hepatitis C virus transgenic mice fed an atherogenic high-fat diet.

[Nature Communications] Investigators showed that super-enhancers played a critical role in the transcription of cancer stemness genes as well as pro-metastatic genes, thereby controlling their tumorigenic potential and metastasis.

[Scientific Reports] Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas; however, little is known about their signaling and metabolic pathways.The authors showed that PCSCs have specific and common proteome and lipidome modulations.

[Communications Biology] Scientists indicated that CSCs may enjoy blood perfusion to maintain their stemness features. Targeting the lysophosphatidic acid/protein kinase D -CD36 signaling pathway may have therapeutic potential to curb tumor progression by disrupting the arteriolar niche and effectively eliminating CSCs.

[Cell Death & Differentiation] Scientists demonstrated that SIRT1/CUL4B promoted CSC-like properties, including increased stemness marker expression and sphere formation.