Integrated Lipidomics and Proteomics Reveal Cardiolipin Alterations, Upregulation of HADHA and Long Chain Fatty Acids in Pancreatic Cancer Stem Cells

Pancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas; however, little is known about their signaling and metabolic pathways.The authors showed that PCSCs have specific and common proteome and lipidome modulations.