cardiac fibroblasts

[Journal of Molecular and Cellular Cardiology] Investigators demonstrated marker expression and matrix competency of cardiac fibroblasts developed through a developmentally conserved epicardial pathway as shown next to primary human cardiac fibroblasts.

[Circulation] The authors suggested that ADAMTS proteases were critical for versican degradation in the heart, and that versican accumulation was associated with impaired cardiac function.

[Febs Letters] The authors review the current knowledge of fibroblast interactions in the healthy, diseased and aging heart.

[Scientific Reports] Scientists explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 to assess the cardio-differentiation potential of these cells.

[Cell Stem Cell] Investigators reported that cardiac fibroblasts and mesenchymal progenitors are more hypoxic than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF-1α), and exhibited increased glycolytic metabolism.

[Scientific Reports] Researchers presented a computer vision model to classify and segmented cells containing alpha-smooth muscle actin stress fibers into two classes, with a high degree of accuracy.