cardiac fibroblasts

[Circulation] Researchers addressed the therapeutic potential of histone deacetylases (HDAC) inhibition in a model of established diastolic dysfunction with preserved ejection fraction.

[Signal Transduction and Targeted Therapy] Langendorff system was applied to isolate cardiomyocytes and cardiac fibroblasts from transverse aortic constriction-induced mice.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated using adult cardiac fibroblasts that genetic deletion of G protein-coupled receptor kinase 5 inhibits angiotensin II-mediated fibroblast activation.

[Circulation] 5-HT2B antagonism resulted in collagen fiber redistribution to thinner collagen fibers which were more anisotropic, enhancing left ventricular contractility, while fibrotic tissue stiffness was decreased, limiting the hypertrophic response of uninjured cardiomyocytes.

[Scientific Reports] Among the 32 neutrophil gelatinase-associated lipocalin (NGAL) inhibitors tested, GPZ614741 and GPZ058225 fully blocked NGAL-induced inflammatory and profibrotic markers in human cardiac fibroblasts and primary mouse kidney fibroblasts.

[Signal Transduction and Targeted Therapy] Scientists summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.