Researchers demonstrated using adult cardiac fibroblasts that genetic deletion of G protein-coupled receptor kinase 5 inhibits angiotensin II-mediated fibroblast activation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Eguchi, A., Coleman, R., Gresham, K., Gao, E., Ibetti, J., Chuprun, J. K., & Koch, W. J. (2021). GRK5 is a regulator of fibroblast activation and cardiac fibrosis. Proceedings of the National Academy of Sciences, 118(5). https://doi.org/10.1073/pnas.2012854118 Cite