Complement Dysregulation Is Associated with Severe COVID-19 Illness

Researchers demonstrated that serum from 58 COVID-19 patients could induce complement-mediated cell death in a functional assay and increase membrane attack complex deposition on the cell surface.
[Haematologica]
Yu, J., Gerber, G. F., Chen, H., Yuan, X., Chaturvedi, S., Braunstein, E. M., & Brodsky, R. A. (2020). Complement dysregulation is associated with severe COVID-19 illness. Haematologica. https://doi.org/10.3324/haematol.2021.279155 Cite
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The Human Amniotic Fluid Stem Cell Secretome Triggers Intracellular Ca2+ Oscillations, NF-κB Nuclear Translocation and Tube Formation in Human Endothelial Colony-Forming Cells

The authors found that the secretome obtained by human amniotic fluid-derived stem cells undergoing hypoxic preconditioning induced intracellular Ca2+ oscillations by promoting extracellular Ca2+ entry through Transient Receptor Potential Vanilloid 4.
[Journal of Cellular and Molecular Medicine]
Balducci, V., Faris, P., Balbi, C., Costa, A., Negri, S., Rosti, V., Bollini, S., & Moccia, F. (n.d.). The human amniotic fluid stem cell secretome triggers intracellular Ca2+ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.16739 Cite
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Exosomal microRNA-1246 from Human Umbilical Cord Mesenchymal Stem Cells Potentiates Myocardial Angiogenesis in Chronic Heart Failure

Cardiac function, myocardial infarction area, apoptosis, and angiogenesis were all evaluated in a CHF rat model following treatment with human umbilical cord MSC-derived exosomes.
[Cell Biology International]
Wang, Z., Gao, D., Wang, S., Lin, H., Wang, Y., & Xu, W. (n.d.). Exosomal microRNA-1246 from human umbilical cord mesenchymal stem cells potentiates myocardial angiogenesis in chronic heart failure. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11664 Cite
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Clonal Hematopoiesis of Indeterminate Potential (CHIP): Linking Somatic Mutations, Hematopoiesis, Chronic Inflammation and Cardiovascular Disease

Investigators summarize emerging research on CHIP, the mechanisms underlying its important role in propagating inflammation and accelerating cardiovascular disease, and new studies detailing the role of associated risk factors and co-morbidities that increase CHIP prevalence.
[Journal of Molecular and Cellular Cardiology]
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Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function after Ischemia-Reperfusion Injury

Human induced pluripotent stem cell derived cardiomyocytes as well as ex vivo and in vivo models of ischemia-reperfusion injury were used to test the efficacy of ASIC1a inhibitors as pre- and post-conditioning therapeutic agents.
[Circulation]
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ADAR2 Increases in Exercised Heart and Protects against Myocardial Infarction and Doxorubicin-Induced Cardiotoxicity

AAV9-mediated cardiac specific ADAR2 overexpression attenuated acute myocardial infarction (MI), MI remodeling and doxorubicin-induced cardiotoxicity. In vitro, overexpression of ADAR2 inhibited doxorubicin-induced cardiomyocyte apoptosis but also induced neonatal rat cardiomyocyte proliferation.
[Molecular Therapy]
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Hematopoietic and Cardiac GPR55 Synchronize Post-Myocardial Infarction Remodeling

Scientists investigated the role of GPR55 in cardiac physiology and post-myocardial infarction (MI) inflammation and remodeling. Global GPR55 deficiency mitigated MI-induced fetal gene re-programming and cardiomyocyte hypertrophy, culminating in aggravated LV dilatation and infarct expansion.
[Scientific Reports]
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U.S. FDA Approves Finerenone for the Treatment of Patients with Chronic Kidney Disease Associated with Type 2 Diabetes

Bayer announced that the US FDA has approved finerenone, the first non-steroidal, selective mineralocorticoid receptor (MR) antagonist, under the brand name Kerendia®.
[Bayer, Inc.]
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A Paradigm Shift in Cell-Free Approach: The Emerging Role of MSCs-Derived Exosomes in Regenerative Medicine

The authors discuss the therapeutic potential of MSC- exosomes as an innovative approach in the context of regenerative medicine and highlight the recent knowledge on MSC- exosomes in translational medicine, focusing on in vivo researches.
[Journal of Translational Medicine]
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Comprehensive Assessment of Myocardial Remodeling in Ischemic Heart Disease by Synchrotron Propagation Based X-Ray Phase Contrast Imaging

The authors used X-ray Phase Contrast Imaging to comprehensively quantify ischemic remodeling of different myocardial structures, from cell to organ level, in a rat model of myocardial infarction.
[Scientific Reports]
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M1 Macrophage-Derived Exosomes Transfer miR-222 to Induce Bone Marrow Mesenchymal Stem Cell Apoptosis

The authors investigated the role of hypoxia/serum deprivation-induced M1-type macrophage-derived exosomes on bone marrow MSC viability, migration, and apoptosis.
[Laboratory Investigation]
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