Researchers demonstrated that serum from 58 COVID-19 patients could induce complement-mediated cell death in a functional assay and increase membrane attack complex deposition on the cell surface.
The authors found that the secretome obtained by human amniotic fluid-derived stem cells undergoing hypoxic preconditioning induced intracellular Ca2+ oscillations by promoting extracellular Ca2+ entry through Transient Receptor Potential Vanilloid 4.
[Journal of Cellular and Molecular Medicine]
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Balducci, V., Faris, P., Balbi, C., Costa, A., Negri, S., Rosti, V., Bollini, S., & Moccia, F. (n.d.). The human amniotic fluid stem cell secretome triggers intracellular Ca2+ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.16739 Cite
Cardiac function, myocardial infarction area, apoptosis, and angiogenesis were all evaluated in a CHF rat model following treatment with human umbilical cord MSC-derived exosomes.
[Cell Biology International]
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Investigators summarize emerging research on CHIP, the mechanisms underlying its important role in propagating inflammation and accelerating cardiovascular disease, and new studies detailing the role of associated risk factors and co-morbidities that increase CHIP prevalence.
[Journal of Molecular and Cellular Cardiology]
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Human induced pluripotent stem cell derived cardiomyocytes as well as ex vivo and in vivo models of ischemia-reperfusion injury were used to test the efficacy of ASIC1a inhibitors as pre- and post-conditioning therapeutic agents.
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AAV9-mediated cardiac specific ADAR2 overexpression attenuated acute myocardial infarction (MI), MI remodeling and doxorubicin-induced cardiotoxicity. In vitro, overexpression of ADAR2 inhibited doxorubicin-induced cardiomyocyte apoptosis but also induced neonatal rat cardiomyocyte proliferation.
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Scientists investigated the role of GPR55 in cardiac physiology and post-myocardial infarction (MI) inflammation and remodeling. Global GPR55 deficiency mitigated MI-induced fetal gene re-programming and cardiomyocyte hypertrophy, culminating in aggravated LV dilatation and infarct expansion.
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Bayer announced that the US FDA has approved finerenone, the first non-steroidal, selective mineralocorticoid receptor (MR) antagonist, under the brand name Kerendia®.
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The authors discuss the therapeutic potential of MSC- exosomes as an innovative approach in the context of regenerative medicine and highlight the recent knowledge on MSC- exosomes in translational medicine, focusing on in vivo researches.
[Journal of Translational Medicine]
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The authors used X-ray Phase Contrast Imaging to comprehensively quantify ischemic remodeling of different myocardial structures, from cell to organ level, in a rat model of myocardial infarction.
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The authors investigated the role of hypoxia/serum deprivation-induced M1-type macrophage-derived exosomes on bone marrow MSC viability, migration, and apoptosis.
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