Tag Archives: myocardial infarction

Injectable Hydrogel with MSNs/microRNA-21-5p Delivery Enables Both Immunomodification and Enhanced Angiogenesis for Myocardial Infarction Therapy in Pigs

Scientists developed a microRNA-21-5p delivery system using functionalized mesoporous silica nanoparticles with additional intrinsic therapeutic effects.
[Science Advances]
Li, Y., Chen, X., Jin, R., Chen, L., Dang, M., Cao, H., Dong, Y., Cai, B., Bai, G., Gooding, J. J., Liu, S., Zou, D., Zhang, Z., & Yang, C. (2021). Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Science Advances, 7(9), eabd6740. https://doi.org/10.1126/sciadv.abd6740 Cite
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Immunomodulation for Optimal Cardiac Regeneration: Insights from Comparative Analyses

Comparing the human heart with those of animal models that are capable of cardiac regeneration reveals key differences in the innate and adaptive immune responses to myocardial infarction.
[npj Regenerative Medicine]
Farache Trajano, L., & Smart, N. (2021). Immunomodulation for optimal cardiac regeneration: insights from comparative analyses. Npj Regenerative Medicine, 6(1), 1–11. https://doi.org/10.1038/s41536-021-00118-2 Cite
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Microenvironment Stiffness Requires Fetal Extracellular Proteins to Increase Cardiomyocyte Proliferation in Neonatal Mouse

Using neonatal mouse hearts and ventricle explants of various stiffness, researchers investigated the synergistic effects of microenvironment stiffness and exogenous fetal ECM on cardiac post-injury response, cardiomyocyte proliferation, cytoskeleton organization, and YAP activity.
[Biophysical Journal]
Wang, X., Park, P., & Senyo, S. E. (2021). Microenvironment Stiffness Requires Fetal Extracellular Proteins to Increase Cardiomyocyte Proliferation in Neonatal Mouse. Biophysical Journal, 120(3), 236a. https://doi.org/10.1016/j.bpj.2020.11.1559 Cite
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Exosomal LINC00174 Derived from Vascular Endothelial Cells Attenuates Myocardial Ischemia-Reperfusion Injury via p53-Mediated Autophagy and Apoptosis

The authors investigated the regulation of specific long non-coding RNAs on the progression of ischemia/reperfusion injury. They identified and characterized the exosomes derived from mouse primary aortic endothelial cells.
[Molecular Therapy-Nucleic Acids]
Su, Q., Lv, X.-W., Xu, Y.-L., Cai, R.-P., Dai, R.-X., Yang, X.-H., Zhao, W.-K., & Kong, B.-H. (2021). Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial Ischemia-Reperfusion Injury via p53-mediated autophagy and apoptosis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.005 Cite
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Dynamic Effects of Genetic Variation on Gene Expression Revealed following Hypoxic Stress in Cardiomyocytes

To study inter-individual differences in response to hypoxia, scientists established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals.
[eLife]
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First Trimester Placental Mesenchymal Stem Cells Improve Cardiac Function of Rat after Myocardial Infarction via Enhanced Neovascularization

First trimester placental chorion mesenchymal stem cells (CMSCs) and third trimester CMSCs were isolated and characterized, and then they were subjected to in vitro endothelial cell differentiation induction and tube formation to evaluate angiogenic ability.
[Heliyon]
Yu, S., You, X., Liang, H., Li, Y., Fu, Y., Zhang, X., Hu, X., An, J., Xu, Y., & Li, F. (2021). First trimester placental mesenchymal stem cells improve cardiac function of rat after myocardial infarction via enhanced neovascularization. Heliyon, 7(1). https://doi.org/10.1016/j.heliyon.2021.e06120 Cite
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GRK5 Is a Regulator of Fibroblast Activation and Cardiac Fibrosis

Researchers demonstrated using adult cardiac fibroblasts that genetic deletion of G protein-coupled receptor kinase 5 inhibits angiotensin II-mediated fibroblast activation.
[Proceedings of the National Academy of Sciences of the United States of America]
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3D Bioprinting of High Cell-Density Heterogeneous Tissue Models through Spheroid Fusion within Self-Healing Hydrogels

Scientists bioprinted iPSC-derived cardiac microtissue models with spatially controlled cardiomyocyte and fibroblast cell ratios to replicate the structural and functional features of scarred cardiac tissue that arise following myocardial infarction, including reduced contractility and irregular electrical activity.
[Nature Communications]
Daly, A. C., Davidson, M. D., & Burdick, J. A. (2021). 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels. Nature Communications, 12(1), 753. https://doi.org/10.1038/s41467-021-21029-2 Cite
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Single Cell Sequencing Reveals Endothelial Plasticity with Transient Mesenchymal Activation after Myocardial Infarction

The authors explored the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing.
[Nature Communications]
Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E.-M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S.-I., … Dimmeler, S. (2021). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nature Communications, 12(1), 681. https://doi.org/10.1038/s41467-021-20905-1 Cite
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Antifibrotic Effect of Novel Neutrophil Gelatinase-Associated Lipocalin Inhibitors in Cardiac and Renal Disease Models

Among the 32 neutrophil gelatinase-associated lipocalin (NGAL) inhibitors tested, GPZ614741 and GPZ058225 fully blocked NGAL-induced inflammatory and profibrotic markers in human cardiac fibroblasts and primary mouse kidney fibroblasts.
[Scientific Reports]
Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models | Scientific Reports. (n.d.). Retrieved January 28, 2021, from https://www.nature.com/articles/s41598-021-82279-0 Cite
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Regulation of Cardiomyocyte Fate Plasticity: A Key Strategy for Cardiac Regeneration

Scientists summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.
[Signal Transduction and Targeted Therapy]
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