Scientists developed a microRNA-21-5p delivery system using functionalized mesoporous silica nanoparticles with additional intrinsic therapeutic effects.
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Li, Y., Chen, X., Jin, R., Chen, L., Dang, M., Cao, H., Dong, Y., Cai, B., Bai, G., Gooding, J. J., Liu, S., Zou, D., Zhang, Z., & Yang, C. (2021). Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Science Advances, 7(9), eabd6740. https://doi.org/10.1126/sciadv.abd6740 Cite
Comparing the human heart with those of animal models that are capable of cardiac regeneration reveals key differences in the innate and adaptive immune responses to myocardial infarction.
[npj Regenerative Medicine]
Using neonatal mouse hearts and ventricle explants of various stiffness, researchers investigated the synergistic effects of microenvironment stiffness and exogenous fetal ECM on cardiac post-injury response, cardiomyocyte proliferation, cytoskeleton organization, and YAP activity.
The authors investigated the regulation of specific long non-coding RNAs on the progression of ischemia/reperfusion injury. They identified and characterized the exosomes derived from mouse primary aortic endothelial cells.
[Molecular Therapy-Nucleic Acids]
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Su, Q., Lv, X.-W., Xu, Y.-L., Cai, R.-P., Dai, R.-X., Yang, X.-H., Zhao, W.-K., & Kong, B.-H. (2021). Exosomal LINC00174 derived from vascular endothelial cells attenuates myocardial Ischemia-Reperfusion Injury via p53-mediated autophagy and apoptosis. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.02.005 Cite
To study inter-individual differences in response to hypoxia, scientists established an in vitro model of induced pluripotent stem cell-derived cardiomyocytes from 15 individuals.
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First trimester placental chorion mesenchymal stem cells (CMSCs) and third trimester CMSCs were isolated and characterized, and then they were subjected to in vitro endothelial cell differentiation induction and tube formation to evaluate angiogenic ability.
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Yu, S., You, X., Liang, H., Li, Y., Fu, Y., Zhang, X., Hu, X., An, J., Xu, Y., & Li, F. (2021). First trimester placental mesenchymal stem cells improve cardiac function of rat after myocardial infarction via enhanced neovascularization. Heliyon, 7(1). https://doi.org/10.1016/j.heliyon.2021.e06120 Cite
Researchers demonstrated using adult cardiac fibroblasts that genetic deletion of G protein-coupled receptor kinase 5 inhibits angiotensin II-mediated fibroblast activation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Scientists bioprinted iPSC-derived cardiac microtissue models with spatially controlled cardiomyocyte and fibroblast cell ratios to replicate the structural and functional features of scarred cardiac tissue that arise following myocardial infarction, including reduced contractility and irregular electrical activity.
The authors explored the kinetics and individual cellular responses of endothelial cells after myocardial infarction by using single cell RNA sequencing.
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Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E.-M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S.-I., … Dimmeler, S. (2021). Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nature Communications, 12(1), 681. https://doi.org/10.1038/s41467-021-20905-1 Cite
Among the 32 neutrophil gelatinase-associated lipocalin (NGAL) inhibitors tested, GPZ614741 and GPZ058225 fully blocked NGAL-induced inflammatory and profibrotic markers in human cardiac fibroblasts and primary mouse kidney fibroblasts.
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Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models | Scientific Reports. (n.d.). Retrieved January 28, 2021, from https://www.nature.com/articles/s41598-021-82279-0 Cite
Scientists summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.
[Signal Transduction and Targeted Therapy]
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