Tag Archives: myocardial infarction

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METTL3 Improves Cardiomyocyte Proliferation upon Myocardial Infarction via Upregulating miR-17-3p in a DGCR8-Dependent Manner

Due to the role of methyltransferase-like 3 (METTL3) in the physiological proliferation of cardiomyocytes, researchers aimed to determine whether METTL3 could also promote cardiomyocyte proliferation under pathological conditions and to elucidate the underlying mechanism.

[Cell Death Discovery]

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Conquering the Cytokine Storm in COVID-19-Induced ARDS Using Placenta-Derived Decidua Stromal Cells

Researchers conducted a safety and efficacy study that included ten patients with a median age of 50 years with COVID-19-induced acute respiratory distress syndrome (ARDS).

[Journal of Cellular and Molecular Medicine]

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Cell Proliferation Fate Mapping Reveals Regional Cardiomyocyte Cell-Cycle Activity in Subendocardial Muscle of Left Ventricle

Scientists found that the majority of cycling cardiomyocytes were positioned in the subendocardial muscle of the left ventricle, especially in the papillary muscles

[Nature Communications]

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The circRNA CNEACR Regulates Necroptosis of Cardiomyocytes through Foxa2 Suppression

Scientists found that the level of mmu_circ_000338, a cardiac- necroptosis-associated circRNA, was reduced in hypoxia-reoxygenation exposed cardiomyocytes and ischemia-reperfusion-injured mice hearts.

[Cell Death & Disease]

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Cardiomyocyte microRNA-150 Confers Cardiac Protection and Directly Represses Proapoptotic Small Proline–Rich Protein 1A

Scientists demonstrated that potentially novel conditional cardiomyocyte–specific miR-150 knock out in mice worsened maladaptive cardiac remodeling after myocardial infarction.

[JCI Insight]

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Abstract Graphical Abstract

Inhibition of MicroRNA-30a Alleviates Vascular Remodeling in Pulmonary Arterial Hypertension

Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.

[Molecular Therapy-Nucleic Acids]

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Insulin-Like Growth Factor Binding Protein-1 Regulates HIF-1α-1α Degradation to Inhibit Apoptosis in Hypoxic Cardiomyocytes

The authors demonstrated that hypoxia up-regulated IGFBP-1 and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α was essential to IGFBP-1 function in cellular apoptosis.

[Cell Death Discovery]

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Asiatic Acid Alleviates Ischemic Myocardial Injury in Mice by Modulating Mitophagy- and Glycophagy-Based Energy Metabolism

Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.

[Acta Pharmacologica Sinica]

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Abstract

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Pharmacologic Therapy for Engraftment Arrhythmia Induced by Transplantation of Human Cardiomyocytes

Investigators used a porcine model to provide proof-of-concept evidence that a combination of amiodarone and ivabradine could effectively suppress engraftment arrhythmia.

[Stem Cell Reports]

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Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4

Using LysMCre-mediated mammalian STE20-like protein kinase 1/2 (Mst1/2)-deficient mice, researchers found that MST1 deficiency exacerbated cardiac dysfunction after myocardial infarction.

[Circulation Research]

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Abstract