Progesterone, via Yes-Associated Protein (YAP), Promotes Cardiomyocyte Proliferation and Cardiac Repair

Progesterone supplementation enhanced cardiomyocyte proliferation in a progesterone receptor‐dependent manner. Progesterone up‐regulated YAP expression and knockdown of YAP by small interfering RNA reduced progesterone‐mediated cardiomyocyte proliferative effect.
[Cell Proliferation]
Lan, C., Cao, N., Chen, C., Qu, S., Fan, C., Luo, H., Zeng, A., Yu, C., Xue, Y., Ren, H., Li, L., Wang, H., Jose, P. A., Xu, Z., & Zeng, C. (n.d.). Progesterone, via yes-associated protein, promotes cardiomyocyte proliferation and cardiac repair. Cell Proliferation, n/a(n/a), e12910. https://doi.org/10.1111/cpr.12910 Cite
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Liposomal Delivery of Azithromycin Enhances Its Immunotherapeutic Efficacy and Reduces Toxicity in Myocardial Infarction

Scientists investigated the immunomodulatory role of a liposomal azithromycin formulation in a clinically relevant model to enhance its therapeutic potency and avoid off-target effects.
[Scientific Reports]
Al-Darraji, A., Donahue, R. R., Tripathi, H., Peng, H., Levitan, B. M., Chelvarajan, L., Haydar, D., Gao, E., Henson, D., Gensel, J. C., Feola, D. J., Venditto, V. J., & Abdel-Latif, A. (2020). Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction. Scientific Reports, 10(1), 16596. https://doi.org/10.1038/s41598-020-73593-0 Cite
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Nanoparticle-Encapsulated siRNAs for Gene Silencing in the Haematopoietic Stem-Cell Niche

Researchers report the design and in vivo performance of systemically injected lipid–polymer nanoparticles encapsulating small interfering RNA, for the silencing of genes in bone-marrow endothelial cells.
[Nature Biomedical Engineering]
Krohn-Grimberghe, M., Mitchell, M. J., Schloss, M. J., Khan, O. F., Courties, G., Guimaraes, P. P. G., Rohde, D., Cremer, S., Kowalski, P. S., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S. P., Wojtkiewicz, G. R., Nayar, R., Frodermann, V., Hulsmans, M., … Nahrendorf, M. (2020). Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nature Biomedical Engineering, 1–14. https://doi.org/10.1038/s41551-020-00623-7 Cite
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HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk

HUVECs or human coronary artery endothelial cells were pre-treated with the antiretrovirals abacavir sulphate, tenofovir disoproxil fumarate or tenofovir alafenamide.
[Circulation Research]
Khawaja Akif A, Taylor Kirk A, Lovell Andrew O, Nelson Mark, Gazzard Brian, Boffito Marta, & Emerson Michael. (n.d.). HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.119.316477 Cite
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Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies

The authors briefly survey cell sources and delivery strategies, along with biomaterials and their processing techniques, developed for myocardial infarction treatment. Key issues and challenges, as well as recommendations for future research, are also discussed.
[Advanced Healthcare Materials]
He, L., & Chen, X. (n.d.). Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies. Advanced Healthcare Materials, n/a(n/a), 2001175. https://doi.org/10.1002/adhm.202001175 Cite
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Expansion of Human Mesenchymal Stem/Stromal Cells (hMSCs) in Bioreactors Using Microcarriers: Lessons Learnt and What the Future Holds

The authors examine the various factors to be considered when developing a hMSC manufacturing process using microcarriers and bioreactors and their potential impact on the final product.
[Biotechnology Advances]
Silva Couto, P., Rotondi, M. C., Bersenev, A., Hewitt, C. J., Nienow, A. W., Verter, F., & Rafiq, Q. A. (2020). Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds. Biotechnology Advances, 107636. https://doi.org/10.1016/j.biotechadv.2020.107636 Cite
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Autophagy and Cardiac Diseases: Therapeutic Potential of Natural Products

The authors focus on the role of autophagy in various cardiac diseases and the pharmacological basis and therapeutic potential of reported natural products in cardiac diseases by modifying autophagic processes.
[Medicinal Research Reviews]
Wu, X., Liu, Z., Yu, X.-Y., Xu, S., & Luo, J. (n.d.). Autophagy and cardiac diseases: Therapeutic potential of natural products. Medicinal Research Reviews, n/a(n/a). https://doi.org/10.1002/med.21733 Cite
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LRP6 Downregulation Promotes Cardiomyocyte Proliferation and Heart Regeneration

Researchers investigated the role of lipoprotein receptor-related protein 6 (LRP6) in heart repair through regulation of cardiomyocyte proliferation. Lrp6 deficiency increased cardiomyocyte cell cycle activity in neonatal, juvenile and adult mice.
[Cell Research]
Wu, Y., Zhou, L., Liu, H., Duan, R., Zhou, H., Zhang, F., He, X., Lu, D., Xiong, K., Xiong, M., Zhuang, J., Liu, Y., Li, L., Liang, D., & Chen, Y.-H. (2020). LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration. Cell Research, 1–13. https://doi.org/10.1038/s41422-020-00411-7 Cite
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Transplanted Microvessels Improve Pluripotent Stem Cell–Derived Cardiomyocyte Engraftment and Cardiac Function after Infarction in Rats

Ready-made microvessels promoted a sixfold increase in human induced pluripotent stem cell–derived cardiomyocyte (hiPSC-CM) survival and superior functional recovery when compared to hiPSC-CMs transplanted alone or cotransplanted with a suspension of dissociated endothelial cells in infarcted rat hearts.
[Science Translational Medicine]
Sun, X., Wu, J., Qiang, B., Romagnuolo, R., Gagliardi, M., Keller, G., Laflamme, M. A., Li, R., & Nunes, S. S. (2020). Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats. Science Translational Medicine, 12(562). https://doi.org/10.1126/scitranslmed.aax2992 Cite
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Hypoxia-Induced Downregulation of Cyclooxygenase 2 Leads to the Loss of Immunoprivilege of Allogeneic Mesenchymal Stem Cells

The authors performed in vitro and in vivo studies to elucidate the mechanisms responsible for the change in the immunophenotype of MSCs from immunoprivileged to immunogenic under ischemic conditions.
[FASEB Journal]
Sareen, N., Abu‐El‐Rub, E., Ammar, H. I., Yan, W., Sequiera, G. L., ShamsEldeen, A. M., Moudgil, M., Dhingra, R., Shokry, H. S., Rashed, L. A., Kirshenbaum, L. A., & Dhingra, S. (n.d.). Hypoxia-induced downregulation of cyclooxygenase 2 leads to the loss of immunoprivilege of allogeneic mesenchymal stem cells. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.202001478R Cite
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Crosstalk between Cardiomyocytes and Noncardiomyocytes Is Essential to Prevent Cardiomyocyte Apoptosis Induced by Proteasome Inhibition

Scientists report a cardiomyocyte-specific survival upon proteasome inhibition in a heterogeneous culture consisting of cardiomyocytes and other three major cardiac cell types.
[Cell Death & Disease]
Guo, F., Zhang, C.-C., Yin, X.-H., Li, T., Fang, C.-H., & He, X.-B. (2020). Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-03005-8 Cite
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