Increased Release of Serotonin from Rat Primary Isolated Adult Cardiac Myofibroblasts

Rat primary cardiac fibroblasts were isolated and transformed into myofibroblasts using 5 ng/ml TGF-β1. Transformation of cells to myofibroblasts was confirmed with the presence of α-smooth muscle actin using Western blot.
[Scientific Reports]
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The Extracellular Matrix Glycoprotein ADAMTSL2 Is Increased in Heart Failure and Inhibits TGFβ Signaling in Cardiac Fibroblasts

The authors aimed to determine a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs-like (ADAMTSL) levels in failing hearts, and to elucidate the role of ADAMTSL2 in fibrosis using cultured human cardiac fibroblasts
[Scientific Reports]
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Secretory Products from Epicardial Adipose Tissue Induce Adverse Myocardial Remodeling after Myocardial Infarction by Promoting Reactive Oxygen Species Accumulation

Rat cardiomyocyte cell line H9C2 and primary rat cardiac fibroblasts were cultured in conditioned media generated from epicardial adipose tissue (EAT) of rats in the myocardial infarction 4-week group (EAT-CM). Functionally, EAT-CM enlarged the cell surface area of H9C2 cells and reinforced cardiac fibroblast activation into myofibroblasts by elevating intracellular reactive oxygen species levels.
[Cell Death & Disease]
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Myocardial Fibrosis Reversion via rhACE2-Electrospun Fibrous Patch for Ventricular Remodeling Prevention

By multiple in vitro studies, the rhACE2 patch demonstrated effectiveness in reducing cardiomyocytes apoptosis under hypoxia stress and inhibiting cardiac fibroblasts proliferation, which gave evidence for its in vivo efficacy.
[NPJ Regenerative Medicine]
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IGF-1 Protects against Angiotensin II-Induced Cardiac Fibrosis by Targeting αSMA

Researchers investigated the roles of IGF-1 signaling during agonist-induced cardiac fibrosis and evaluated the molecular mechanisms in cultured cardiac fibroblasts. They found severe interstitial fibrosis in angiotensin II/phenylephrine infused myofibroblast-specific IGF-1R knockout mice compared to the wild-type mice.
[Cell Death & Disease]
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Cell Type-Specific Roles of PAR1 in Coxsackievirus B3 Infection

Investigators determined the effect of cell type-specific deletion of protease-activated receptor 1 (PAR1) in cardiac myocytes and cardiac fibroblasts on Coxsackievirus B3-induced myocarditis.
[Scientific Reports]
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Direct Reprogramming as a Route to Cardiac Repair

In recent years, direct reprogramming of resident cardiac fibroblasts to induced cardiac-like myocytes has emerged as a promising therapeutic strategy to repurpose the fibrotic response of the injured heart toward a functional myocardium.
[Seminars in Cell & Developmental Biology]
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Non-Viral Approaches for Somatic Cell Reprogramming into Cardiomyocytes

Scientists review the recent progress in development of non-viral approaches to directly reprogram somatic cells towards cardiomyocytes and their therapeutic application for heart regeneration.
[Seminars in Cell & Developmental Biology]
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Translational Perspectives on Cardiac Reprogramming

Over the last decade, remarkable progresses have been made on cardiac reprogramming, particularly focusing on how to enhance conversion of fibroblasts to induced cardiomyocyte-like cells in vitro. The author discusses progresses and challenges of cardiac reprogramming in the translational context.
[Seminars in Cell & Developmental Biology]
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A Transcriptional Switch Governs Fibroblast Activation in Heart Disease

Scientists used single-cell epigenomic analysis of hearts dynamically exposed to bromodomain and extra-terminal domain inhibitors to reveal a reversible transcriptional switch that underlied the activation of fibroblasts.
[Nature]
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Engineering Aligned Human Cardiac Muscle Using Developmentally Inspired Fibronectin Micropatterns

Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.
[Scientific Reports]
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