The Double Face of miR-320: Cardiomyocytes-Derived miR-320 Deteriorated While Fibroblasts-Derived miR-320 Protected against Heart Failure Induced by Transverse Aortic Constriction

Langendorff system was applied to isolate cardiomyocytes and cardiac fibroblasts from transverse aortic constriction-induced mice.
[Signal Transduction and Targeted Therapy]
Zhang, X., Yuan, S., Li, H., Zhan, J., Wang, F., Fan, J., Nie, X., Wang, Y., Wen, Z., Chen, Y., Chen, C., & Wang, D. W. (2021). The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction. Signal Transduction and Targeted Therapy, 6(1), 1–12. https://doi.org/10.1038/s41392-020-00445-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

GRK5 Is a Regulator of Fibroblast Activation and Cardiac Fibrosis

Researchers demonstrated using adult cardiac fibroblasts that genetic deletion of G protein-coupled receptor kinase 5 inhibits angiotensin II-mediated fibroblast activation.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract
Bookmark

No account yet? Register

0
Share

Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling after Myocardial Infarction

5-HT2B antagonism resulted in collagen fiber redistribution to thinner collagen fibers which were more anisotropic, enhancing left ventricular contractility, while fibrotic tissue stiffness was decreased, limiting the hypertrophic response of uninjured cardiomyocytes.
[Circulation]
Snider J. Caleb, Riley Lance A., Mallory Noah T., Bersi Matthew R., Umbarkar Prachi, Gautam Rekha, Zhang Qinkun, Mahadevan-Jansen Anita, Hatzopoulos Antonis K., Maroteaux Luc, Lal Hind, & Merryman W. David. (n.d.). Targeting 5-HT2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling after Myocardial Infarction. Circulation, 0(0). https://doi.org/10.1161/CIRCULATIONAHA.120.051517 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Antifibrotic Effect of Novel Neutrophil Gelatinase-Associated Lipocalin Inhibitors in Cardiac and Renal Disease Models

Among the 32 neutrophil gelatinase-associated lipocalin (NGAL) inhibitors tested, GPZ614741 and GPZ058225 fully blocked NGAL-induced inflammatory and profibrotic markers in human cardiac fibroblasts and primary mouse kidney fibroblasts.
[Scientific Reports]
Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models | Scientific Reports. (n.d.). Retrieved January 28, 2021, from https://www.nature.com/articles/s41598-021-82279-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Regulation of Cardiomyocyte Fate Plasticity: A Key Strategy for Cardiac Regeneration

Scientists summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.
[Signal Transduction and Targeted Therapy]
Full Article
Bookmark

No account yet? Register

0
Share

6-Gingerol Protects against Cardiac Remodeling by Inhibiting the p38 Mitogen-Activated Protein Kinase Pathway

Neonatal rat cardiomyocytes and cardiac fibroblasts were used to validate the protective effects of 6-gingerol in response to phenylephrine and transforming growth factor-β challenge.
[Acta Pharmacologica Sinica]
Abstract
Bookmark

No account yet? Register

0
Share

Eosinophils Improve Cardiac Function after Myocardial Infarction

Mechanistic studies revealed roles of eosinophil IL4 and cationic protein mEar1 in blocking H2O2– and hypoxia-induced mouse and human cardiomyocyte death, TGF-β-induced cardiac fibroblast Smad2/3 activation, and TNF-α-induced neutrophil adhesion on the heart endothelial cell monolayer.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

0
Share

Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction

The role of cardiac IgE receptor (FcεR1) signaling in pathological cardiac remodeling was explored in vivo by FcεR1 genetic depletion, anti-IgE antibodies, and bone-marrow transplantation. The roles of immunoglobulin E (IgE)-FcεR1 pathway were further evaluated in vitro in primary cultured rat cardiomyocytes and cardiac fibroblasts.
[Circulation]
Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction | Circulation. (n.d.). Retrieved December 14, 2020, from https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.047852 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Membrane Nanotubes Facilitate the Propagation of Inflammatory Injury in the Heart upon Overactivation of the β-Adrenergic Receptor

β-adrenergic receptor (β-AR) overactivation induced inflammasome activation in both the cardiomyocytes and cardiac fibroblasts of mice hearts following a subcutaneous injection of isoproterenol, a selective agonist of β-AR.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling

In rat and mouse models of ischemic heart failure, investigators showed that miR-30d gain of function improves cardiac function, decreases myocardial fibrosis, and attenuates cardiomyocyte apoptosis.
[Circulation Research]
Abstract
Bookmark

No account yet? Register

0
Share

Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies

The authors briefly survey cell sources and delivery strategies, along with biomaterials and their processing techniques, developed for myocardial infarction treatment. Key issues and challenges, as well as recommendations for future research, are also discussed.
[Advanced Healthcare Materials]
Abstract
Bookmark

No account yet? Register

0
Share
Share