IGF-1 Protects against Angiotensin II-Induced Cardiac Fibrosis by Targeting αSMA

Researchers investigated the roles of IGF-1 signaling during agonist-induced cardiac fibrosis and evaluated the molecular mechanisms in cultured cardiac fibroblasts. They found severe interstitial fibrosis in angiotensin II/phenylephrine infused myofibroblast-specific IGF-1R knockout mice compared to the wild-type mice.
[Cell Death & Disease]
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Cell Type-Specific Roles of PAR1 in Coxsackievirus B3 Infection

Investigators determined the effect of cell type-specific deletion of protease-activated receptor 1 (PAR1) in cardiac myocytes and cardiac fibroblasts on Coxsackievirus B3-induced myocarditis.
[Scientific Reports]
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Direct Reprogramming as a Route to Cardiac Repair

In recent years, direct reprogramming of resident cardiac fibroblasts to induced cardiac-like myocytes has emerged as a promising therapeutic strategy to repurpose the fibrotic response of the injured heart toward a functional myocardium.
[Seminars in Cell & Developmental Biology]
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Non-Viral Approaches for Somatic Cell Reprogramming into Cardiomyocytes

Scientists review the recent progress in development of non-viral approaches to directly reprogram somatic cells towards cardiomyocytes and their therapeutic application for heart regeneration.
[Seminars in Cell & Developmental Biology]
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Translational Perspectives on Cardiac Reprogramming

Over the last decade, remarkable progresses have been made on cardiac reprogramming, particularly focusing on how to enhance conversion of fibroblasts to induced cardiomyocyte-like cells in vitro. The author discusses progresses and challenges of cardiac reprogramming in the translational context.
[Seminars in Cell & Developmental Biology]
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A Transcriptional Switch Governs Fibroblast Activation in Heart Disease

Scientists used single-cell epigenomic analysis of hearts dynamically exposed to bromodomain and extra-terminal domain inhibitors to reveal a reversible transcriptional switch that underlied the activation of fibroblasts.
[Nature]
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Engineering Aligned Human Cardiac Muscle Using Developmentally Inspired Fibronectin Micropatterns

Scientists identified cell–cell and cell-ECM interactions in the microenvironment of the early four-chambered vertebrate heart that drive cardiomyocyte organization and alignment.
[Scientific Reports]
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Transthyretin Amyloid Fibrils Alter Primary Fibroblast Structure, Function and Inflammatory Gene Expression

Investigators suggested that transthyretin deposited in tissue extracellular matrix may affect both the structure, function and gene expression of cardiac fibroblasts.
[American Journal of Physiology-Heart and Circulatory Physiology]
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AAV-Mediated YAP Expression in Cardiac Fibroblasts Promotes Inflammation and Increases Fibrosis

Researchers leveraged adeno-associated virus (AAV) to target cardiac fibroblasts and demonstrated that chronic Yes-associated protein (YAP) expression upregulated indices of fibrosis and inflammation in the absence of additional stress.
[Scientific Reports]
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A Predictive In Vitro Risk Assessment Platform for Pro-Arrhythmic Toxicity Using Human 3D Cardiac Microtissues

Scientists used human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3-dimensional microtissues to create an improved in vitro platform for assessing pro-arrhythmic cardiotoxicity.
[Scientific Reports]
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Multiplexed Targeting of miRNA-210 in Stem Cell-Derived Extracellular Vesicles Promotes Selective Regeneration in Ischemic Hearts

Under hypoxic conditions, the authors observed that ASCmiR-210 inhibited apoptosis by modulating protein tyrosine phosphatase 1B and death-associated protein kinase 1.
[Experimental and Molecular Medicine]
Song, B.-W., Lee, C. Y., Kim, R., Kim, W. J., Lee, H. W., Lee, M. Y., Kim, J., Jeong, J.-Y., & Chang, W. (2021). Multiplexed targeting of miRNA-210 in stem cell-derived extracellular vesicles promotes selective regeneration in ischemic hearts. Experimental & Molecular Medicine, 1–14. https://doi.org/10.1038/s12276-021-00584-0 Cite
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