cardiomyocytes

[Cell Death & Disease] Scientists found that the level of mmu_circ_000338, a cardiac- necroptosis-associated circRNA, was reduced in hypoxia-reoxygenation exposed cardiomyocytes and ischemia-reperfusion-injured mice hearts.

[Communications Biology] The down-regulation of cell cycle genes and the up-regulation of the mature myofilament genes in cardiomyocytes in vitro (iCMs) reached intermediate levels between those of fetal and neonatal cardiomyocytes. Cardiomyo-miRs were up-regulated in iCMs.

[Experimental Cell Research] Researchers studied the construction of cardiac ECM-based 3D hydrogel and its effects on cell behaviors. The results indicated that cellular compartments could be efficiently removed from heart tissue via sodium dodecyl sulfonate- and Triton X-100-mediated decellularization, remaining the natural fibrous network structure and major proteins.

[Stem Cell Reviews and Reports] Understanding biological mechanisms involved in the long-term alcohol exposure-induced cardiotoxicity is pivotal to the discovery of therapeutic strategies. Cardiomyocytes derived from human pluripotent stem cells were treated with clinically relevant doses of ethanol for various durations up to five weeks.

[Cell Biology International] Researchers showed that methyltransferase-like 3 (METTL3) was downregulated in mice ischemia-reperfusion (I/R) myocardial tissues and hypoxic/re-oxygenated (H/R) cardiomyocytes, and upregulation of METTL3 attenuated I/R and H/R-induced cell apoptosis.

[Toxicology in Vitro] Scientists investigated the chemical sensitivity of the ESTc carried out under 20% O2, using ESCs cultured under either 20% O2 or 5% O2. ESC viability was more sensitive to valproic acid but less sensitive to flusilazole when cultured under 5% versus 20% O2.