cardiomyocytes

[Molecular Therapy-Nucleic Acids] Researchers investigated the role of miR-30a in the pulmonary artery smooth muscle cells remodeling of pulmonary arterial hypertension.

[Cell Death Discovery] The authors demonstrated that hypoxia up-regulated IGFBP-1 and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α was essential to IGFBP-1 function in cellular apoptosis.

[Cell Death Discovery] Investigators defined the underlying role of histone deacetylase 4 (HDAC4) and miR-206 in the pathological process of myocardial ischemia-reperfusion injury (MIRI). Up-regulation of HDAC4 and down-regulation of miR-206 occurred in rat myocardial tissues and cardiomyocytes in MIRI.

[Current Biology] Researchers showed that human induced pluripotent stem cell-derived cardiomyocytes from patients with rs2229774 and who suffered doxorubicin-induced cardiotoxicity were more sensitive to doxorubicin.

[Acta Pharmacologica Sinica] Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.

[Science Advances] Investigators indicated that interleukin-11 signaling in endothelial cells antagonized profibrotic transforming growth factor–β signaling and endothelial-to-mesenchymal transition, limiting scarring and promoting cardiomyocyte repopulation, after injury.