Histone Deacetylase HDAC4 Participates in the Pathological Process of Myocardial Ischemia-Reperfusion Injury via MEKK1/JNK Pathway by Binding to miR-206

Investigators defined the underlying role of histone deacetylase 4 (HDAC4) and miR-206 in the pathological process of myocardial ischemia-reperfusion injury (MIRI). Up-regulation of HDAC4 and down-regulation of miR-206 occurred in rat myocardial tissues and cardiomyocytes in MIRI.