Insulin-Like Growth Factor Binding Protein-1 Regulates HIF-1α-1α Degradation to Inhibit Apoptosis in Hypoxic Cardiomyocytes

The authors demonstrated that hypoxia up-regulated IGFBP-1 and HIF-1α protein expression in cardiomyocytes. Subsequent assays showed that IGFBP-1 suppression decreased HIF-1α expression and inhibited hypoxia-induced apoptosis in cardiomyocytes, which was reversed by HIF-1α overexpression, indicating that HIF-1α was essential to IGFBP-1 function in cellular apoptosis.