caspase-3

[Cancer Biology & Therapy] Scientists found that the expression of matrix metallopeptidase 1 (MMP1) was up-regulated in cutaneous squamous cell carcinoma (CSCC) cells, and knockdown of MMP1 suppressed cell proliferation and invasion in CSCC.

[Nature] Researchers advanced a concept that several Enterobacteriaceae, including patient-derived clinical isolates, had an efficient growth strategy to exploit soluble factors that were released from dying gut epithelial cells.

[Journal of Pharmacy and Pharmacology] With the help of cell cytotoxicity, the effect of tonkinensine B on MDA-MB-231 cells was investigated. The levels of key apoptosis-associated proteins Bcl-2, Bax, caspase-9, caspase-3 and AKT in MDA-MB-231 cells were analysed to determine whether tonkinensine B caused apoptosis via the mitochondrial pathway.

[Cell Biochemistry and Biophysics] Scientists showed that treatment with burn serum could significantly upregulate the phosphorylation level of extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase and the expression of cleaved caspase-3 and downregulated the expression of Bcl2 when compared with those in negative control of small interfering RNA transfected H9C2 cells

[Circulation Research] The authors characterized direct SARS-CoV-2-platelet interactions using in vitro studies with purified infectious virions and samples from infected patients.

[Scientific Reports] Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.