caspase-3

[FASEB Journal] To investigate the role of R349P Des in mechanical loading, scientists stimulated the sciatic nerve of wild-type littermates and animals carrying the mutation causing a lengthening contraction of the dorsi flexor muscles.

[Naunyn-Schmiedebergs Archives of Pharmacology] HepG2 and Huh7 cells were treated with different concentrations of L-leucine, L-glutamine, or L-methionine and cell viability was determined using MTT assay. Insulin-like growth factor 1, phosphorylated ribosomal protein S6 kinase, p53, and cyclin D1 protein levels were assayed using ELISA.

[Cardiovascular Toxicology] To investigate the role of CAIII in the apoptosis of myocytes under hypoxic conditions and facilitate the strategy for treating hypoxia-induced damage, in vitro experiments in H9c2 were employed.

[Phytotherapy Research] Scientists investigated the anticancer potential of abundant monophenols from cinnamon, namely, cinnamaldehyde, cinnamic acid, and eugenol, by hypothesizing that they possess proteasome inhibitory activities capable of suppressing cancer cell proliferation and inducing apoptosis.

[Journal of Cellular and Molecular Medicine] Scientists investigated the potential link between DOX-induced cell death and pyroptosis in two human breast cancer cell lines and proved that treatment with DOX reduced cell viability in a dose-dependent way and induced pyroptosis morphology.

[Journal of Molecular Endocrinology] A mechanism of dexamethasone-induced pancreatic β-cell apoptosis through the TRAIL pathway was investigated in cultured cells and isolated mouse islets.