cell culture

[Journal of Molecular Biology] The authors review the importance of patient-derived tumor organoids as a model to study chromosomal instability in cancers of the gastrointestinal tract.

[Scientific Reports] Researchers presented human patient induced pluripotent stem cell-derived neurons cultured on densely-spaced spiky silicon nanowire arrays which showed mature electrophysiological characteristics after only 20 days of culturing.

[Biomedical Materials] Evaluations of angiogenesis and osteogenesis were conducted via both in vitro cell culture using human bone marrow mesenchymal stromal cells and in vivo implantation using a rat model of calvarial defect.

[Islets] Scientists review the attempts over the past decade, to utilize the organoid cell culture principles in order to identify, expand, and differentiate the adult pancreatic stem cells from different compartments of mouse and human pancreata.

[Journal of Pharmacology and Experimental Therapeutics] Pharmacokinetic assessment of hydroxychloroquine (HCQ) in non-tumor bearing mice following intraperitoneal dosing established 60 mg/kg as the human equivalent dose of HCQ in mice.

[Movement Disorders] The authors explore the opportunities and challenges resulting from the convergence of organoid high-throughput screening and AI-driven data analytics and outline potential future avenues toward the discovery of novel mechanisms and drugs in Parkinson's disease research.