cell proliferation

[Cell Death & Disease] Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.

[Cancers] Researchers demonstrated that long non-coding RNA prostate androgen regulated transcript 1 (PART1) was enriched in TNBCs. Knockdown of PART1 in TNBC cell lines and a patient-derived xenograft decreased cell proliferation, migration, tumor growth, and mammosphere formation potential.

[EMBO Molecular Medicine] Using mouse mammary tissue ex vivo, scientists showed that testosterone-related progestins induced the progesterone receptor (PR) target and mediator of PR signaling-induced cell proliferation receptor activator of NF-κB ligand, whereas progestins with anti-androgenic properties in reporter assays did not.

[Scientific Reports] Researchers performed a knockdown of miR-148a using anti-miRNA oligonucleotides (AMOs) and investigated the effect on breast cancer cell proliferation, which was significantly suppressed by AMO flanked by interstrand cross-linked duplexes, whereas single-stranded AMOs had no effect.

[Scientific Reports] Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.

[Scientific Reports] Investigators generated CYP3A4-expressing Caco-2 cells and attempted to establish a model that could simultaneously evaluate drug absorption and metabolism.