Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

Researchers investigated whether the blockade of ABCC1 affects prostate cancer cell proliferation using both in vitro and in vivo models.
[Cancers]
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Roniciclib Down-Regulates Stemness and Inhibits Cell Growth by Inducing Nucleolar Stress in Neuroblastoma

Scientists found that neurospheres derived from neuroblastoma stem-like cells showed a homogeneous staining for several key nucleolar proteins, such as Nucleolin, Nucleophosmin-1, Glypican-2 and PES-1.
[Scientific Reports]
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Oncogenic Smurf1 Promotes PTEN Wild-Type Glioblastoma Growth by Mediating PTEN Ubiquitylation

Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
[Oncogene]
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Human Ex Vivo Spinal Cord Slice Culture as a Useful Model of Neural Development, Lesion, and Allogeneic Neural Cell Therapy

Scientists applied experimental allogeneic human neural cell therapy after injury in ex vivo spinal cord slices.
[Stem Cell Research & Therapy]
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Lentiviral Gene Therapy Vectors Encoding VIP Suppressed Diabetes-Related Inflammation and Augmented Pancreatic Beta-Cell Proliferation

The therapeutic efficacy of LentiVIP was tested in a multiple low-dose STZ-induced animal model of type 1 diabetes. LentiVIP delivery into diabetic animals reduced hyperglycemia, improved glucose tolerance, and prevented weight loss.
[Gene Therapy]
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LINC00324 Affects Non-Small Cell Lung Cancer Cell Proliferation and Invasion through Regulation of the miR-139-5p/IGF1R Axis

Scientists demonstrated whether LINC00324 participates in non-small cell lung cancer pathogenesis through other molecular mechanism.
[Molecular and Cellular Biochemistry]
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Interactome of miRNAs and Transcriptome of Human Umbilical Cord Endothelial Cells Exposed to Short-Term Simulated Microgravity

Deep high-throughput sequencing approach allowed researchers to analyze the miRNA and mRNA expression profiles in HUVECS cultured under gravity, and stimulated microgravity achieved with a clinostat.
[NPJ Microgravity]
Kasiviswanathan, D., Chinnasamy Perumal, R., Bhuvaneswari, S., Kumar, P., Sundaresan, L., Philip, M., Puthenpurackal Krishnankutty, S., & Chatterjee, S. (2020). Interactome of miRNAs and transcriptome of human umbilical cord endothelial cells exposed to short-term simulated microgravity. Npj Microgravity, 6(1), 1–10. https://doi.org/10.1038/s41526-020-00108-6 Cite
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LRCH1 Deficiency Enhances LAT Signalosome Formation and CD8+ T Cell Responses against Tumors and Pathogens

Investigators demonstrated that LRCH1 directly bound linker for activation of T cells (LAT), reduced LAT phosphorylation and interaction with GRB2, and also promoted the endocytosis of LAT.
[Proceedings of the National Academy of Sciences of the United States of America]
Liu, C., Xu, X., Han, L., Wan, X., Zheng, L., Li, C., Liao, Z., Xiao, J., Zhong, R., Zheng, X., Wang, Q., Li, Z., Chen, H., Wei, B., & Wang, H. (2020). LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2000970117 Cite
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Progesterone Receptor Membrane Component 1 Promotes the Growth of Breast Cancers by Altering the Phosphoproteome and Augmenting EGFR/PI3K/AKT Signalling

Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
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Ubiquilin Proteins Regulate EGFR Levels and Activity in Lung Adenocarcinoma Cells

The authors investigated a link between ubiquilin and the oncogene epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells.
[Journal of Cellular Biochemistry]
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Role of HSP70 in Response to (Thermo)Radiotherapy: Analysis of Gene Expression in Canine Osteosarcoma Cells by RNA-seq

Researchers investigated up- and down-regulated genes in response to (thermo)radiotherapy in HSP70 proficient and deficient canine osteosarcoma cell line, and functional role of HSP70 in the mechanism of thermoradiosensitization.
[Scientific Reports]
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