cell proliferation

[Frontiers in Oncology] Investigators analyzed the clinical impact of Sdc-1 expression by analysis of public gene expression datasets and studied the effect of an overexpression of Sdc-1 and its membrane-bound and soluble forms on the malignant properties of the human cervical carcinoma cell line HeLa through functional analysis.

[Oncogene] Researchers identified a key regulator of macropinocytosis for the survival of tumor cells in a low amino acid environment in pancreatic ductal adenocarcinoma.

[Science] Investigators generated a human model for tuberous sclerosis complex (TSC) by growing cerebral organoids from patients who carried mutations in TSC2.

[Scientific Reports] In controlled in vitro assays it was found that Acanthus ebracteatus Vahl. extract and verbascoside at various concentrations induced dermal papilla cell proliferation which was indicated by an increase in the number of cells in the S and G2/M phases of the cell cycle.

[Cell Biochemistry and Biophysics] Scientists investigated the function of itraconazole-induced AMP-activated protein kinase alpha (AMPKα) in melanoma progression through ERK signaling.

[Translational Oncology] Silencing of TIM-3 shuttled by MV3 cells-derived exosomes improved CD4+ T cell immune function and inhibited macrophage M2 polarization to attenuate the growth and metastasis of melanoma cells.