cell proliferation

[Biochemistry and Cell Biology] Wistar-Kyoto rats and spontaneously hypertensive rats were used to detect the expression of Angptl2. Angiotensin II stimulated vascular smooth muscle cells to mimic hypertension in vitro.

[Journal of Cell Science] Researchers assessed a potential role of TAZ on theSmad7/β-catenin complex in muscle cells. They documented functional interactions between Smad7, TAZ and β-catenin in myogenic cells.

[Science Immunology] Researchers showed that SOCS1 was a critical node integrating both IL-2 and IFN-γ signals to block multiple downstream signaling pathways abrogating CD4+ T helper 1 (TH1) cell response.

[Scientific Reports] Researchers characterized and investigated the effects of transient receptor potential melastatin-8 (TRPM8) modulators in prostate cancer aggressiveness disclosing the molecular mechanism underlying their biological activity.

[Cancer Cell International] Researchers noted that heterogeneous nuclear ribonucleoprotein K (HnRNPK) emerged as an important player in the carcinogenesis process of prostate cancer (PrCa). miR-206 and miR-613 suppressed HnRNPK expression by targeting its 3’-UTR in PrCa cell lines in which HnRNPK was overexpressed.

[Clinical and Translational Oncology] Scientists investigated the involvement of the SDF-1/CXCR4 axis in the process of bone marrow mesenchymal stem cells (BMMSC) homing in prostate cancer (PCa) in vivo and in vitro and suggested that BMMSCs could home and promote the proliferation and migration of PCa through the SDF-1/CXCR4 axis.