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cell proliferation

Local Anesthetic Levobupivacaine Inhibits Stemness of Osteosarcoma Cells by Epigenetically Repressing MAFB Though Reducing KAT5 Expression

[Aging] Scientists identified that the treatment of levobupivacaine suppressed proliferation of osteosarcoma cells in vitro.

Faciogenital Dysplasia 5 Supports Cancer Stem Cell Traits in Basal-Like Breast Cancer by Enhancing EGFR Stability

[Science Translational Medicine] Scientists performed the basal-like breast cancers (BLBCs) tissue microarray–based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 abundance was associated with poor prognosis in BLBCs.

Efficient Isolation of Human Gingival Stem Cells in a New Serum-Free Medium Supplemented with Platelet Lysate and Growth Hormone for Osteogenic Differentiation Enhancement

[Stem Cell Research & Therapy] Gingival stem cell isolation and thawing under these conditions were successful, and no significant DNA lesions were detected.

CD4+ T Cell Dysfunction in Severe COVID-19 Disease is TNFα/TNFRI-Dependent

[American Journal of Respiratory and Critical Care Medicine] Researchers characterized the functional SARS-CoV-2 T cell responses in severe versus recovered, mild COVID-19 patients to determine whether differences were detectable.

Trefoil Factor 3 Promotes Pancreatic Carcinoma Progression via WNT Pathway Activation Mediated by Enhanced WNT Ligand Expression

[Cell Death & Disease] Researchers observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome.

Pan-KRAS Inhibitors Suppress Proliferation through Feedback Regulation in Pancreatic Ductal Adenocarcinoma

[Acta Pharmacologica Sinica] Two pan-KRAS inhibitors, BI-2852 and BAY-293, were chosen as chemical probes to investigate their antitumor potency in PDAC.

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