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cell proliferation

Novel Role of GPR35 (G-Protein–Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure

[Hypertension] Scientists evaluated the effect of G-protein–coupled receptor 35 on endothelial cell functions and hemodynamic homeostasis.

NADPH Oxidase 5 Has a Crucial Role in Cellular Motility of Colon Cancer Cells

[International Journal of Oncology] NOX5 knockdown significantly inhibited cell migration and invasion in both HCT116 and SW48 cells; however, NOX5 knockdown reduced cell proliferation in only HCT116 cells.

Curcumin Attenuates Adriamycin-Resistance of Acute Myeloid Leukemia by Inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 Axis

[Laboratory Investigation] Scientists investigated the mechanism by which curcumin affected the resistance of acute myeloid leukemia to Adriamycin by regulating HOX transcript antisense RNA (HOTAIR) expression.

Integrated Whole Transcriptome and Small RNA Analysis Revealed Multiple Regulatory Networks in Colorectal Cancer

[Scientific Reports] Computational analysis using Ingenuity Pathway Analysis identified multiple activated signaling networks in colorectal cancer (CRC), including ERBB2, RABL6, FOXM1, and NFKB networks, while functional annotation highlighted activation of cell proliferation and migration as the hallmark of CRC.

CDK15 Promotes Colorectal Cancer Progression via Phosphorylating PAK4 and Regulating β-Catenin/ MEK-ERK Signaling Pathway

[Cell Death & Differentiation] Knockdown of CDK15 suppressed cell proliferation and anchorage-independent growth of colorectal cancer cells and inhibited tumor growth in cell line-derived xenograft model.

Association of RDM1 with Osteosarcoma Progression via Cell Cycle and MEK/ERK Signaling Pathway Regulation

[Journal of Cellular and Molecular Medicine] Researchers explored the connection between RAD52 motif-containing 1 (RDM1) and osteosarcoma (OS) progression, as well as the underlying mechanism. It was found that RDM1 was highly expressed in OS cells compared with human osteoblast cell.

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