cell proliferation

[Prostate] Investigators confirmed that GAS5, a long noncoding RNA, could interact and suppress androgen receptor (AR) transactivation in CRPC C4-2 cells and revealed the important role of GAS5 in AR axis activity regulation and CRPC progression.

[Cell Reports] Scientists found primary medulloblastoma tumors globally displayed decreased expression of GABA transaminase, the protein responsible for GABA metabolism, compared with normal cerebellum.

[Scientific Reports] Investigators elucidated the effects of glutamine (Gln) supplementation on the cellular muscle development of low birth weight and normal birth weight piglets. Cell culture experiments indicated that Gln promoted cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered.

[Cell Death & Disease] Researchers performed a comprehensive analysis for prognostic significance of U2AF1 mutations in acute myeloid leukemia (AML) cohort. Functional analysis of U2AF1S34F mutation was performed in vitro.

[Dermatology] Scientists studied the effects of psoriatic dermal mesenchymal stem cells on the proliferation, differentiation, and migration of keratinocytes and the underlying mechanisms.

[Acta Pharmacologica Sinica] Researchers demonstrated that the level of KCNN4 in pancreatic ductal adenocarcinoma was abnormally elevated, and the overexpression of KCNN4 was induced by transcription factor AP-1.