Medulloblastoma Uses GABA Transaminase to Survive in the Cerebrospinal Fluid Microenvironment and Promote Leptomeningeal Dissemination

By
Justin.choi
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Scientists found primary medulloblastoma tumors globally displayed decreased expression of GABA transaminase, the protein responsible for GABA metabolism, compared with normal cerebellum.
[Cell Reports]
Martirosian, V., Deshpande, K., Zhou, H., Shen, K., Smith, K., Northcott, P., Lin, M., Stepanosyan, V., Das, D., Remsik, J., Isakov, D., Boire, A., Feyter, H. D., Hurth, K., Li, S., Wiemels, J., Nakamura, B., Shao, L., Danilov, C., … Neman, J. (2021). Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Reports, 35(13). https://doi.org/10.1016/j.celrep.2021.109302 Cite
Abstract