cell reprogramming

[Cell Proliferation] RNA-seq, quantitative RT-PCR and western blot analysis were applied to study the role of RNF20 and H2B ubiquitination during mouse somatic cell reprogramming.

[Cell Death & Disease] Investigators showed that truncation of the DIDO gene altered RNA splicing and transcription termination in ESC and mouse embryo fibroblasts, which affected genes involved in both differentiation and reprogramming.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists examined epigenome remodeling at the onset of human nuclear reprogramming by profiling human fibroblasts after fusion with murine ESCs. Efficient reprogramming of human fibroblasts to iPSCs was achieved by transduction with vectors expressing SOX2, KLF4, and inducible dnAP-1, demonstrating that dnAP-1 can substitute for exogenous human OCT4.

[Communications Biology] Researchers established tumor-specific tumor-infiltrating lymphocytes (TIL)-derived iPS cells with human colorectal cancer specimens to confirm their hypothesis that the anti-tumor effect could be enhanced by TIL regeneration.

[Nature Medicine] Researchers identified a significant pathology-associated increase in hepatic conventional dendritic cells (cDC) and further defined their source as non-alcoholic fatty liver disease-induced boost in cycling of cDC progenitors in the bone marrow.

[Experimental and Molecular Medicine] Researchers used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique.