XCR1+ Type 1 Conventional Dendritic Cells Drive Liver Pathology in Non-alcoholic Steatohepatitis

By
Justin.choi
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Researchers identified a significant pathology-associated increase in hepatic conventional dendritic cells (cDC) and further defined their source as non-alcoholic fatty liver disease-induced boost in cycling of cDC progenitors in the bone marrow.
[Nature Medicine]
Deczkowska, A., David, E., Ramadori, P., Pfister, D., Safran, M., At The, B., Giladi, A., Jaitin, D. A., Barboy, O., Cohen, M., Yofe, I., Gur, C., Shlomi-Loubaton, S., Henri, S., Suhail, Y., Qiu, M., Kam, S., Hermon, H., Lahat, E., … Amit, I. (2021). XCR1 + type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis. Nature Medicine, 1–12. https://doi.org/10.1038/s41591-021-01344-3 Cite
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