cell transplantation

[Bone Marrow Transplantation] The authors review current critical points of hematopoietic stem cell transplantation using alternative donors and assessing recently reported safety issues of gene therapy methods, and conclude that, although a breakthrough, the safety of gene therapy remains to be established.

[Blood Advances] Investigators evaluated dasatinib-based two-step induction with the primary endpoint of three-year event-free survival as treatment for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia.

[British Journal of Haematology] Scientists investigated post-transplant outcomes in 1722 myelodysplastic syndrome patients following Allogeneic hematopoietic-cell transplantation with fludarabine/treosulfan, reduced-intensity conditioning or myeloablative-conditioning.

[Biomaterials] The authors engineered alginate hydrogels to present integrin- and syndecan-binding peptides alone or in combination to introduce bioactive features into the alginate gels.

[International Immunopharmacology] To better understand the role of MSC in the prevention and treatment of graft-versus-host disease, umbilical cord derived MSCs were pre-treated with Chinese medicine Asarinin and IFN-γ.

[Scientific Reports] Investigators analyzed expression of DNAM-1 in leukemic cells of AML patients. Interaction of DNAM-1 with its ligands CD112 and CD155 induced release of the immunomodulatory cytokines IL-6, IL-8 IL-10 and TNF-α by AML cells and DNAM-1 expression correlated with a more differentiated phenotype.