DNAM-1/CD226 Is Functionally Expressed on Acute Myeloid Leukemia (AML) Cells and Is Associated with Favorable Prognosis

Investigators analyzed expression of DNAM-1 in leukemic cells of AML patients. Interaction of DNAM-1 with its ligands CD112 and CD155 induced release of the immunomodulatory cytokines IL-6, IL-8 IL-10 and TNF-α by AML cells and DNAM-1 expression correlated with a more differentiated phenotype.