Investigators highlight two areas in the field of HSC research, which just started to unlock the possibilities provided by novel biomaterials, in vitro blood production and studying the pathophysiology of the niche in vitro.
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Chatterjee, C., Schertl, P., Frommer, M., Ludwig-Husemann, A., Mohra, A., Dilger, N., Naolou, T., Meermeyer, S., Bergmann, T. C., Calleja, A. A., & Lee-Thedieck, C. (2021). Rebuilding the hematopoietic stem cell niche: recent developments and future prospects. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2021.03.061 Cite
Researchers conducted retrospective multicenter analysis of patients diagnosed with acute myeloid leukemia or myelodysplastic syndromes who had hematological relapse after allogeneic hematopoietic stem cell transplantation and were treated with azacitidine for this indication.
[European Journal of Haematology]
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Drozd‐Sokołowska, J., Karakulska‐Prystupiuk, E., Biecek, P., Kobylińska, K., Piekarska, A., Dutka, M., Waszczuk‐Gajda, A., Mądry, K., Kopińska, A., Gołos, A., Góra‐Tybor, J., Szwedyk, P., Bołkun, Ł., Czyż, A., Giebel, S., Basak, G. W., & Dwilewicz‐Trojaczek, J. (n.d.). Azacitidine for relapse of acute myeloid leukemia or myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation, multicenter PALG analysis. European Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/ejh.13628 Cite
Investigators retrospectively analyzed adult patients with acute lymphoblastic leukemia who underwent their first allogeneic stem cell transplantation in first or second complete remission between 2012 and 2018, either from a T cell replete Haplo or matched sibling donor donor.
[Journal of Hematology & Oncology]
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Nagler, A., Labopin, M., Houhou, M., Aljurf, M., Mousavi, A., Hamladji, R.-M., Al Zahrani, M., Bondarenko, S., Arat, M., Angelucci, E., Koc, Y., Gülbas, Z., Sica, S., Bourhis, J. H., Canaani, J., Brissot, E., Giebel, S., & Mohty, M. (2021). Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Journal of Hematology & Oncology, 14(1), 53. https://doi.org/10.1186/s13045-021-01065-7 Cite
Scientist found that only when human photoreceptor precursor cells were pre‐incubated with PKX‐001 prior to transplantation, did the cells integrate and mature into cone photoreceptors expressing S‐opsin or L/M opsin.
[Journal of Tissue Engineering and Regenerative Medicine]
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Viringipurampeer, I. A., Yanai, A., Nizamudheen, V. S., Gregory‐Evans, C. Y., & Gregory‐Evans, K. (n.d.). Photoreceptor precursor cell integration into rodent retina after treatment with novel glycopeptide PKX-001. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/term.3193 Cite
Scientists investigated the interaction between CD304 expression on myeloid-derived suppressor cells and galectin-1 from malignant plasma cells in the context of autologous stem cell transplantation for multiple myeloma.
[Cancer Immunology Research]
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Targeted therapy has markedly improved outcomes for pediatric chronic myelogenous leukemia, while raising a number of clinical questions, including the possibility of treatment-free remission and long-term health implications of prolonged tyrosine kinase inhibitors exposure at a young age.
[Current Oncology Reports]
The Acute Leukemia Working Party/European Society for Blood and Marrow Transplantation registry was used to evaluate the outcomes of adult patients with acute lymphoblastic leukemia who underwent hematopoietic cell transplantation during 2011 through 2015 and compared them with the outcomes of those who underwent transplantation during 2016 through 2018.
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Nagler, A., Labopin, M., Koc, Y., Angelucci, E., Tischer, J., Arat, M., Pioltelli, P., Bernasconi, P., Chiusolo, P., Diez‐Martin, J. L., Sanz, J., Ciceri, F., Peric, Z., Giebel, S., Canaani, J., & Mohty, M. (n.d.). Outcome of T-cell–replete haploidentical stem cell transplantation improves with time in adults with acute lymphoblastic leukemia: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Cancer, n/a(n/a). https://doi.org/https://doi.org/10.1002/cncr.33522 Cite
The authors present a multi-parameter linear regression model capable of identifying cord blood units that would process poorly, despite meeting established pre-process total nucleated cell and CD34+ quality thresholds.
Scientists analyzed bone marrow-MSCs from 66 patients after allo-hematopoietic stem cell transplantation, including 33 with active chronic graft-versus-host disease and 33 without chronic graft-versus-host disease.
[Cell Death & Disease]
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Qi, H., Ye, Y., Suo, Y., Qu, H., Zhang, H., Yang, K., Fan, Z., Huang, F., Xuan, L., Chen, Y., Jin, H., & Liu, Q. (2021). Wnt/β-catenin signaling mediates the abnormal osteogenic and adipogenic capabilities of bone marrow mesenchymal stem cells from chronic graft-versus-host disease patients. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03570-6 Cite
Researchers investigated the feasibility and safety of MRI-guided transplantation of glial restricted precursors and mesenchymal stem cells in dogs suffering from ALS-like disease, degenerative myelopathy.
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Investigators provide an overview of contributions to gene therapy made by German clinical and research institutions.
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