The Impact of Donor Type on the Outcome of Pediatric Patients with Very High Risk Acute Lymphoblastic Leukemia. A Study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG

Investigators demonstrated the impact of donor type on overall results of allogeneic stem cell transplantation for very-high risk pediatric acute lymphoblastic leukemia with worse results when using mismatched donor stem cell source.
[Bone Marrow Transplantation]
Dalle, J.-H., Balduzzi, A., Bader, P., Pieczonka, A., Yaniv, I., Lankester, A., Bierings, M., Yesilipek, A., Sedlacek, P., Ifversen, M., Svec, P., Toporski, J., Gungor, T., Wachowiak, J., Glogova, E., Poetschger, U., & Peters, C. (2020). The impact of donor type on the outcome of pediatric patients with very high risk acute lymphoblastic leukemia. A study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01014-x Cite
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Allogeneic Hematopoietic Cell Transplantation Efficacy in Patients with Philadelphia Chromosome-Positive Acute Myeloid Leukemia in Complete Remission

Researchers retrospectively analyzed 4649 acute myeloid leukemia (AML) patients who received allogeneic hematopoietic cell transplantation and were in complete remission. Outcomes of Philadelphia chromosome-positive AML, intermediate-risk, and poor-risk AML patients were compared.
[Bone Marrow Transplantation]
Mizuno, S., Yanada, M., Kawamura, K., Masuko, M., Uchida, N., Ozawa, Y., Iwato, K., Ohashi, K., Ikegame, K., Kim, S.-W., Tanaka, M., Eto, T., Kanda, Y., Fukuda, T., Atsuta, Y., Yano, S., & Takami, A. (2020). Allogeneic hematopoietic cell transplantation efficacy in patients with Philadelphia chromosome-positive acute myeloid leukemia in complete remission. Bone Marrow Transplantation, 1–11. https://doi.org/10.1038/s41409-020-01011-0 Cite
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Donor Stem Cell-Derived Paroxysmal Nocturnal Hemoglobinuria after Umbilical Cord Blood Transplantation

The authors report here a patient with adult T‐cell leukemia/lymphoma, who developed paroxysmal nocturnal hemoglobinuria seven years after umbilical cord blood transplantation.
[European Journal of Haematology]
Nakaya, Y., Nakao, T., Ueda, Y., Takamori, H., Nishimura, J., Tatsumi, N., Tsutsumi, M., Yoshida, M., Yoshimura, T., Hayashi, Y., & Yamane, T. (n.d.). Donor stem cell-derived paroxysmal nocturnal hemoglobinuria after umbilical cord blood transplantation. European Journal of Haematology, n/a(n/a). https://doi.org/10.1111/ejh.13498 Cite
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Utilization and Cost Implications of Hematopoietic Progenitor Cells Stored for a Future Salvage Autologous Transplantation or Stem Cell Boost in Myeloma Patients

In this single-center retrospective study, researchers analyzed the utilization of hematopoietic progenitor cells (HPCs) collected and stored at the time of first autologous hematopoietic cell transplantation in patients with myeloma and the cost implications of HPC collection targets sufficient for two transplants.
[Biology of Blood and Marrow Transplantation]
Chhabra, S., Thapa, B., Szabo, A., Konings, S., D’Souza, A., Dhakal, B., Jerkins, J. H., Pasquini, M. C., Johnson, B. D., Hari, P. N., & Hamadani, M. (2020). Utilization and cost implications of hematopoietic progenitor cells stored for a future salvage autologous transplantation or stem cell boost in myeloma patients. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.07.019 Cite
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90Y-Labeled Anti-CD45 Antibody Allogeneic Hematopoietic Cell Transplantation for High-Risk Multiple Myeloma

To improve disease control without increasing the toxicity of a reduced-intensity allogeneic hematopoietic cell transplantation in multiple myeloma, a Phase I trial was performed using an antibody-radionuclide conjugate targeting CD45 as conditioning.
[Bone Marrow Transplantation]
Tuazon, S. A., Sandmaier, B. M., Gooley, T. A., Fisher, D. R., Holmberg, L. A., Becker, P. S., Lundberg, S. J., Orozco, J. J., Gopal, A. K., Till, B. G., Coffey, D. G., Nartea, M. E., Matesan, M. C., Pagel, J. M., Rajendran, J. G., Press, O. W., Bensinger, W. I., & Green, D. J. (2020). 90 Y-labeled anti-CD45 antibody allogeneic hematopoietic cell transplantation for high-risk multiple myeloma. Bone Marrow Transplantation, 1–8. https://doi.org/10.1038/s41409-020-01000-3 Cite
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Upfront Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma with del(17p) and t(4;14): A Study from the CMWP-EBMT

Researchers analyzed newly diagnosed multiple myeloma patients with del(17p) and/or t(4;14) undergoing either upfront single autologous, tandem autologous or tandem autologous/reduced-intensity allogeneic stem cell transplantation.
[Bone Marrow Transplantation]
Gagelmann, N., Eikema, D.-J., de Wreede, L. C., Rambaldi, A., Iacobelli, S., Koster, L., Caillot, D., Blaise, D., Remémyi, P., Bulabois, C.-E., Passweg, J., Leleu, X., Zver, S., Kobbe, G., Ljungman, P., Chevallier, P., Ringhoffer, M., Martin, M., Salmenniemi, U., … Kröger, N. (2020). Upfront stem cell transplantation for newly diagnosed multiple myeloma with del(17p) and t(4;14): a study from the CMWP-EBMT. Bone Marrow Transplantation, 1–8. https://doi.org/10.1038/s41409-020-01007-w Cite
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Sufficiency for Inducible Caspase-9 Safety Switch in Human Pluripotent Stem Cells and Disease Cells

Researchers used targeted gene editing to introduce the inducible Caspase-9 system into human iPSCs, and then interrogated the efficiency of inducible apoptosis with normal iPSCs as well as diseased iPSCs derived from patients with acute myeloid leukemia.
[Gene Therapy]
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Characteristics of Cells with Engraftment Capacity within CD34+ Cell Population upon G-CSF and Plerixafor Mobilization

Investigators assessed the hematopoietic stem cell content within the CD34+ fraction of graft samples from three groups of patients: 1-Good Mobilizer patients receiving G-CSF only, 2-Poor Mobilizer (PM) patients receiving G-CSF only, 3-PM patients receiving G-CSF + Plerixafor.
[Leukemia]
Mombled, M., Rodriguez, L., Avalon, M., Duchez, P., Vlaski-Lafarge, M., Debeissat, C., Pérard, B., Sawai, K. M., Pasquet, J. M., Bijou, F., Thévenot, F., Cabantous, T., Ivanovic, Z., & Brunet de la Grange, P. (2020). Characteristics of cells with engraftment capacity within CD34+ cell population upon G-CSF and Plerixafor mobilization. Leukemia, 1–12. https://doi.org/10.1038/s41375-020-0982-y Cite
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Mitomycin C Treatment Improves Pancreatic Islet Graft Longevity in Intraportal Islet Transplantation by Suppressing Proinflammatory Response

Researchers present a simple approach for islet preconditioning that uses the antibiotic mitomycin C, which has antitumor activity, to reduce islet immunogenicity and prevent proinflammatory events in an intraportal islet transplantation model.
[Scientific Reports]
Yamane, K., Anazawa, T., Tada, S., Fujimoto, N., Inoguchi, K., Emoto, N., Nagai, K., Masui, T., Okajima, H., Takaori, K., Sumi, S., & Uemoto, S. (2020). Mitomycin C treatment improves pancreatic islet graft longevity in intraportal islet transplantation by suppressing proinflammatory response. Scientific Reports, 10(1), 12086. https://doi.org/10.1038/s41598-020-69009-8 Cite
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Xenogeneic Mesenchymal Stem Cell Transplantation for Mandibular Defect Regeneration

To examine donor cell survival and host immune reaction, pig bone marrow‐derived mesenchymal stem cells were labeled with CM‐DiI, loaded onto gelatin sponge, and transplanted into 5‐mm mandibular defects of immunocompetent and T cell‐deficient athymic rats.
[Xenotransplantation]
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GvHD-Free, Relapse-Free Survival Provides Novel Clues for Optimizing Allogeneic-HSCT for Adult T-Cell Leukemia/Lymphoma

The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma.
[Bone Marrow Transplantation]
Muranushi, H., Shindo, T., Hishizawa, M., Tokunaga, M., Wake, A., Nakano, N., Eto, T., Hidaka, M., Choi, I., Miyamoto, T., Uchida, N., Moriuchi, Y., Miyazaki, Y., Fukuda, T., Ichinohe, T., Atsuta, Y., & Kato, K. (2020). GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma. Bone Marrow Transplantation, 1–12. https://doi.org/10.1038/s41409-020-00996-y Cite
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Regenerative Effects of Human Chondrocyte Sheets in a Xenogeneic Transplantation Model Using Immune‐Deficient Rats

Researchers investigated the regenerative effects of human chondrocyte sheets on articular cartilage in a xenogeneic transplantation model using immune‐deficient rats.
[Journal of Tissue Engineering and Regenerative Medicine]
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