Investigators conducted a multicenter biologic assignment trial comparing reduced-intensity hematopoietic cell transplantation to hypomethylating therapy or best supportive care in subjects 50-75 years of age with intermediate-2 or high-risk de novo myelodysplastic syndromes.
[Journal of Clinical Oncology]
6445212 ARDZCHHN items 1 apa default asc 1
Investigators compared 32 patients who underwent unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period.
[Bone Marrow Transplantation]
6445212 3Q4QAH6V items 1 apa default asc 1
The authors review the historical basis underpinning the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as well as advances in knowledge obtained by defining mechanisms of allo-HSCT activity.
6445212 ECPZBI48 items 1 apa default asc 1
Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.
[Current Stem Cell Research & Therapy]
6445212 QNE6CF5G items 1 apa default asc 1
Fan, X., He, S., Song, H., Yin, W., Zhang, J., Peng, Z., Yang, K., Zhai, X., Zhao, L., Gong, H., Ping, Y., Jiao, X., Zhang, S., Yan, C., Wang, H., Li, R.-K., & Xie, J. (2021). Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism. Stem Cell Research & Therapy, 12(1), 344. https://doi.org/10.1186/s13287-021-02423-5 Cite
Investigators summarize the emerging understanding of apoptosis in mediating mesenchymal stem cell transplant, highlighting the potential of apoptotic extracellular vesicles as cell-free therapeutics.
[Cell Death & Disease]
BlueRock Therapeutics announced the dose administration for the first patient in a Phase I, open-label study of PSC-derived dopaminergic neurons in patients with advanced Parkinson’s disease.
6445212 nan items 1 apa default asc 1
The authors collected samples before and after allogeneic hematopoietic stem cell transplantation from two independent prospective cohorts and investigated the prognostic impact of amplicon-based next-generation sequencing-based assessment.
[Blood Cancer Journal]
6445212 MMY64D3U items 1 apa default asc 1
Kim, H.-J., Kim, Y., Kang, D., Kim, H. S., Lee, J.-M., Kim, M., & Cho, B.-S. (2021). Prognostic value of measurable residual disease monitoring by next-generation sequencing before and after allogeneic hematopoietic cell transplantation in acute myeloid leukemia. Blood Cancer Journal, 11(6), 1–11. https://doi.org/10.1038/s41408-021-00500-9 Cite
Researchers report on the development of an enhanced synergistic combination therapy comprising polyacetal–curcumin nanoconjugate and neural stem cells derived from induced pluripotent stem cells + mesenchymal stem cells treatment as a treatment option for severe sub-acute traumatic spinal cord injury.
[International Journal of Molecular Sciences]
6445212 6IHHPHRV items 1 apa default asc 1
Heartseed Inc. and Novo Nordisk A/S announced that they have entered into a collaboration and licence agreement for the development, manufacturing and commercialisation of Heartseed’s asset HS-001, an investigational cell therapy using purified cardiomyocytes derived from induced pluripotent stem cells, which is currently under development by Heartseed for the treatment of heart failure.
6445212 nan items 1 apa default asc 1
The authors summarize the role of CXCR4 in progression and treatment of acute leukemia, and discuss the potential value of using CXCR4 antagonists as immunosensitizer for graft-vs-leukemia effects of allogeneic HSC transplantation.
The authors reported on 382 COVID-19 patients having undergone allogeneic or autologous hematopoietic cell transplantation reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH).
6445212 SWTJKQDZ items 1 apa default asc 1