Rebuilding the Hematopoietic Stem Cell Niche: Recent Developments and Future Prospects

Investigators highlight two areas in the field of HSC research, which just started to unlock the possibilities provided by novel biomaterials, in vitro blood production and studying the pathophysiology of the niche in vitro.
[Acta Biomaterialia]
Chatterjee, C., Schertl, P., Frommer, M., Ludwig-Husemann, A., Mohra, A., Dilger, N., Naolou, T., Meermeyer, S., Bergmann, T. C., Calleja, A. A., & Lee-Thedieck, C. (2021). Rebuilding the hematopoietic stem cell niche: recent developments and future prospects. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2021.03.061 Cite
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Azacitidine for Relapse of Acute Myeloid Leukemia or Myelodysplastic Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation, Multicenter PALG Analysis

Researchers conducted retrospective multicenter analysis of patients diagnosed with acute myeloid leukemia or myelodysplastic syndromes who had hematological relapse after allogeneic hematopoietic stem cell transplantation and were treated with azacitidine for this indication.
[European Journal of Haematology]
Drozd‐Sokołowska, J., Karakulska‐Prystupiuk, E., Biecek, P., Kobylińska, K., Piekarska, A., Dutka, M., Waszczuk‐Gajda, A., Mądry, K., Kopińska, A., Gołos, A., Góra‐Tybor, J., Szwedyk, P., Bołkun, Ł., Czyż, A., Giebel, S., Basak, G. W., & Dwilewicz‐Trojaczek, J. (n.d.). Azacitidine for relapse of acute myeloid leukemia or myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation, multicenter PALG analysis. European Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/ejh.13628 Cite
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Outcome of Haploidentical versus Matched Sibling Donors in Hematopoietic Stem Cell Transplantation for Adult Patients with Acute Lymphoblastic Leukemia: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Investigators retrospectively analyzed adult patients with acute lymphoblastic leukemia who underwent their first allogeneic stem cell transplantation in first or second complete remission between 2012 and 2018, either from a T cell replete Haplo or matched sibling donor donor.
[Journal of Hematology & Oncology]
Nagler, A., Labopin, M., Houhou, M., Aljurf, M., Mousavi, A., Hamladji, R.-M., Al Zahrani, M., Bondarenko, S., Arat, M., Angelucci, E., Koc, Y., Gülbas, Z., Sica, S., Bourhis, J. H., Canaani, J., Brissot, E., Giebel, S., & Mohty, M. (2021). Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Journal of Hematology & Oncology, 14(1), 53. https://doi.org/10.1186/s13045-021-01065-7 Cite
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Photoreceptor Precursor Cell Integration into Rodent Retina after Treatment with Novel Glycopeptide PKX-001

Scientist found that only when human photoreceptor precursor cells were pre‐incubated with PKX‐001 prior to transplantation, did the cells integrate and mature into cone photoreceptors expressing S‐opsin or L/M opsin.
[Journal of Tissue Engineering and Regenerative Medicine]
Viringipurampeer, I. A., Yanai, A., Nizamudheen, V. S., Gregory‐Evans, C. Y., & Gregory‐Evans, K. (n.d.). Photoreceptor precursor cell integration into rodent retina after treatment with novel glycopeptide PKX-001. Journal of Tissue Engineering and Regenerative Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/term.3193 Cite
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Myeloma-Secreted Galectin-1 Potently Interacts with CD304 on Monocytic Myeloid-Derived Suppressor Cells

Scientists investigated the interaction between CD304 expression on myeloid-derived suppressor cells and galectin-1 from malignant plasma cells in the context of autologous stem cell transplantation for multiple myeloma.
[Cancer Immunology Research]
Lim, J.-Y., Kim, T. W., Ryu, D.-B., Park, S.-S., Lee, S.-E., Kim, B.-S., & Min, C.-K. (2021). Myeloma-secreted galectin-1 potently interacts with CD304 on monocytic myeloid-derived suppressor cells. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0663 Cite
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Chronic Myelogenous Leukemia in Childhood

Targeted therapy has markedly improved outcomes for pediatric chronic myelogenous leukemia, while raising a number of clinical questions, including the possibility of treatment-free remission and long-term health implications of prolonged tyrosine kinase inhibitors exposure at a young age.
[Current Oncology Reports]
Smith, S. M., Hijiya, N., & Sakamoto, K. M. (2021). Chronic Myelogenous Leukemia in Childhood. Current Oncology Reports, 23(4), 40. https://doi.org/10.1007/s11912-021-01025-x Cite
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Outcome of T-Cell-Replete Haploidentical Stem Cell Transplantation Improves with Time in Adults with Acute Lymphoblastic Leukemia: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

The Acute Leukemia Working Party/European Society for Blood and Marrow Transplantation registry was used to evaluate the outcomes of adult patients with acute lymphoblastic leukemia who underwent hematopoietic cell transplantation during 2011 through 2015 and compared them with the outcomes of those who underwent transplantation during 2016 through 2018.
[Cancer]
Nagler, A., Labopin, M., Koc, Y., Angelucci, E., Tischer, J., Arat, M., Pioltelli, P., Bernasconi, P., Chiusolo, P., Diez‐Martin, J. L., Sanz, J., Ciceri, F., Peric, Z., Giebel, S., Canaani, J., & Mohty, M. (n.d.). Outcome of T-cell–replete haploidentical stem cell transplantation improves with time in adults with acute lymphoblastic leukemia: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. Cancer, n/a(n/a). https://doi.org/https://doi.org/10.1002/cncr.33522 Cite
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Predictive Analytics and Cord Blood Banking: Toward Utilization-Based Unit Selection

The authors present a multi-parameter linear regression model capable of identifying cord blood units that would process poorly, despite meeting established pre-process total nucleated cell and CD34+ quality thresholds.
[Cytotherapy]
Wynn, L. A., & Madrigal, A. (2021). Predictive analytics and cord blood banking: toward utilization-based unit selection. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.01.002 Cite
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Wnt/β-Catenin Signaling Mediates the Abnormal Osteogenic and Adipogenic Capabilities of Bone Marrow Mesenchymal Stem Cells from Chronic Graft-versus-Host Disease Patients

Scientists analyzed bone marrow-MSCs from 66 patients after allo-hematopoietic stem cell transplantation, including 33 with active chronic graft-versus-host disease and 33 without chronic graft-versus-host disease.
[Cell Death & Disease]
Qi, H., Ye, Y., Suo, Y., Qu, H., Zhang, H., Yang, K., Fan, Z., Huang, F., Xuan, L., Chen, Y., Jin, H., & Liu, Q. (2021). Wnt/β-catenin signaling mediates the abnormal osteogenic and adipogenic capabilities of bone marrow mesenchymal stem cells from chronic graft-versus-host disease patients. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03570-6 Cite
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Intra-Arterial Transplantation of Stem Cells in Large Animals as a Minimally-Invasive Strategy for the Treatment of Disseminated Neurodegeneration

Researchers investigated the feasibility and safety of MRI-guided transplantation of glial restricted precursors and mesenchymal stem cells in dogs suffering from ALS-like disease, degenerative myelopathy.
[Scientific Reports]
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Retroviral Gene Therapy in Germany with a View on Previous Experience and Future Perspectives

Investigators provide an overview of contributions to gene therapy made by German clinical and research institutions.
[Gene Therapy]
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