cell transplantation

[Cancer Immunology Research] Investigators tested the in vitro effect of different NK cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and target either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.

[International Journal of Hematology] Investigators encountered a case of human platelet antigen 15 (HPA-15) mismatched cord blood transplantation with a high HPA-15b antibody titer. Prolonged poor graft function and megakaryocyte aplasia with sustained high-titer HPA-15b antibodies were attenuated by rituximab therapy, and rapid recovery of hematopoiesis was achieved.

[NPJ Regenerative Medicine] Transplanting SUPT4H1-edited Huntington’s disease (HD)-induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) into the YAC128 HD transgenic mouse model improved motor function compared to unedited HD iPSC-NPCs.

[Clinical Reviews in Allergy & Immunology] The authors overview the current knowledge regarding the therapeutic efficacy of MSCs in systemic sclerosis (SSc), focusing on progresses reported in preclinical and clinical studies using MSCs, as well as challenges and future directions of MSC transplantation as a treatment option for patients with SSc.

[Bone Marrow Transplantation] Therapeutic drug monitoring and individualization of busulfan dosage were essential to improve the efficacy and safety of busulfan-based regimen in Chinese pediatric hematopoietic stem cell transplantation recipients.

[Bone Marrow Transplantation] Investigators used a series of landmark analyses to investigate the association of of graft-versus-host disease in the setting of haploidentical SCT (haploSCT) with post-transplant cyclophosphamide in 805 acute myeloid leukemia patients following haploSCT.