chronic inflammation

[Molecular Psychiatry] The authors describe the current knowledge of the effects of aging on the immune system and the cerebral vasculature and how these changes alter the immune response to stroke and vascular dementia in animal and human studies.

[Cell Death & Disease] Centrosomal P4.1-associated protein (CPAP) could increase the expression of chemokine ligand 16 (CCL-16), an important chemotactic cytokine in human hepatocytes. CCL-16 expression was positively correlated with CPAP and TNF-α mRNA expression in the peritumoral part of hepatocellular carcinoma.

[Blood Advances] Investigators conducted a multicenter, open-label, Phase II, single-arm study of pembrolizumab in patients with DIPSS intermediate 2 or greater primary, post-essential thrombocythemia or post-polycythemia vera myelofibrosis that were ineligible for or were previously treated with ruxolitinib.

[EMBO Reports] The authors showed that secreted frizzled-related protein 1 (SFRP1), a multifunctional regulator of cell-to-cell communication, was part of the cellular crosstalk underlying neuroinflammation.

[Nature Reviews Materials] Scientists discuss how intravital microscopy can reveal regenerative and pathological responses to implants, including wound healing and graft integration, which depend on the time-controlled activation of macrophages and early neovascularization, and adverse reactions.

[Cell Death Discovery] Investigators systematically profile the overall mechanism of radiation-induced liver injury and the effects of radiation on hepatocyte senescence, laying foundations for the development of new therapies.