chronic inflammation

[Cell Reports] The authors identified the microbiota-determined output of the pro-inflammatory metabolite, succinate, and elucidated the pathways that controlled transepithelial succinate absorption and subsequent succinate delivery to macrophages.

[Nature Reviews Rheumatology] The authors describe the importance of lymphocyte-stromal cell interactions in chronic inflammation, with a focus on human disease, using three selected autoimmune and inflammatory diseases.

[Nature Reviews Cancer] Researchers discuss how the hepatic microenvironment adapts to pathologies characterized by chronic inflammation and metabolic alterations. They illustrate how these immunological or metabolic changes alter immunosurveillance and thus hinder or promote the development of primary liver cancer.

[Mucosal Immunology] The authors evaluate the mechanistic underpinnings of murine models of Crohn's disease-ileitis, discuss their phenotypic similarities to human disease, and envisage their further exploitation for the development of novel targeted and personalized therapeutics.

[Scientific Reports] Investigators analyzed the role of dietary salt in TNBS chronic colitis induced in rat, an intestinal fibrosis model, and in human colon fibroblast cells and showed that high-salt diet exacerbated undernutrition and promoted extracellular matrix-associated proteins in fibroblasts.

[Redox Biology] The authors evaluated the effects of cannabidiol, a phytocannabinoid known for its antioxidant and anti-inflammatory properties, on the proteome of keratinocyte membranes exposed to hydrogen peroxide.