chronic kidney disease

[American Journal of Pathology] The authors discuss whether kidney organoids and tubuloids are suitable models for the study of complex human kidney disease and highlights their advantages and limitations compared with monolayer cell culture and animal models.

[Experimental Cell Research] Researchers established an in vitro VC model of vascular smooth muscle cells (VSMCs) and an adenine-induced CKD mouse model.

[PLoS One] Through investigating chronic kidney disease-associated transcriptomics datasets, several proteases were highlighted including members of matrix metalloproteinases and serine proteases.

[Journal of the American Society of Nephrology] Scientists explore the mechanisms and detection of acute kidney injury in tissue culture, with an emphasis on bioengineered approaches such as human kidney organoid models.

[Journal of Tissue Engineering] Researchers investigated the therapeutic effects of exosomes secreted by melatonin-stimulated MSCs on the functional recovery of the kidney in a chronic kidney disease mouse model.

[Communications Biology] Co-cultured using a magnetic spheroid formation approach, conditionally immortalised human podocytes and glomerular endothelial cells deposited mature, organized isoforms of collagen IV and Laminin.