clinical trial

[Magenta Therapeutics, Inc.] Magenta Therapeutics, Inc. announced that it has received a clinical hold letter from the US FDA related to its Investigational New Drug Application filed in June 2021 to initiate a Phase I/II clinical trial of MGTA-117 in patients with acute myeloid leukemia and myelodysplastic syndrome.

[Nature Medicine] Ten of 16 patients with large B cell lymphoma with progressive disease after CAR19 treatment had absent or low CD19.

[Eureka Therapeutics, Inc.] Eureka Therapeutics, Inc. announced the initiation of a Phase I/II clinical trial of ECT204, a GPC3 targeting ARTEMIS® T-cell therapy for the treatment of hepatocellular carcinoma, the predominant type of liver cancer.

[Clinical Cancer Research] Scientists performed transcriptional profiling of tumors from a Phase II clinical trial of platinum chemotherapy for advanced TNBC, revealing a gene expression signature that identified de novo chemorefractory tumors.

[Science Advances] Te authors created an ovarian tumor microenvironment chip that consisted of a platelet-perfused tumor microenvironment and recapitulated platelet extravasation and its consequences.

[OSE Immunotherapeutics SA (GlobeNewswire, Inc.)] OSE Immunotherapeutics SA announced a voluntary and temporary pause of enrollment and dosing in its ongoing Phase I clinical trial for CoVepiT, the company’s investigational prophylactic COVID-19 vaccine candidate.