colorectal cancer

[Cell Death & Disease] Researchers reported that METTL14, a key component of N6-methyladenosine methylation, was functionally related to the inhibition of ARRDC4/ZEB1 signaling and to the consequent suppression of colorectal cancer metastasis.

[Journal of Cellular Biochemistry] MiR-1290 was discovered for the first time in human embryonic stem cells, and under typical physiological situations, plays an essential role in neuronal differentiation and neural stem cell proliferation.

[Nucleic Acids Research] Scientists translated a newly developed pooled RNA-seq methodology onto a superhydrophobic microwell array chip to realize an assay of genome-wide RNA output unified with phenotypic data.

[Translational Oncology] Investigators found that overexpression of Rec8 meiotic recombination protein (Rec8) facilitated the migration and invasion of colorectal cancer cells (CRC) in vitro and promoted the liver metastasis of CRC in vivo.

[Aging] Scientists explored the efficacy of anemoside B4 (AB4) in 5-Fluorouracil (FU)-based chemotherapy in colorectal cancer cells and the underlying molecular mechanisms. They indicated a significant synergistic activity of AB4 in 5-FU treated colorectal cancer cells

[Biochemical Pharmacology] MICAL1 has been reported to be involved in the malignant processes of several types of cancer cells, however, the roles of MICAL1 in colorectal cancer (CRC) have not been well-characterized. Researchers investigated the cellular functions and molecular mechanisms of MICAL1 in CRCs.