colorectal cancer

[Bioengineered] Investigators found that RNF220 was upregulated in colorectal cancer in patients and cell models. RT-PCR assay was used to compare differences between expression levels of RNF220 in colorectal tumor and normal tissues.

[Molecular Cancer Research] Researchers identified the cell surface binding partner of Reg4 and dissected its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results.

[Cancer Research] Researchers revealed that delivery of miR-122 was associated with downregulation of key genes in involved in metastatic and cancer inflammation pathways, including several pro-inflammatory factors, matrix metalloproteinases, and other extracellular matrix degradation enzymes.

[Cancer Stem Cell News, Intestinal Cell News] The authors observed elevated expression of full-length ECT2 protein in preneoplastic colon adenomas, driven by increased ECT2 mRNA abundance and associated with APC tumor suppressor loss.

[Cell Death Discovery] The authors demonstrated that MMP1 derived from tumor-associated macrophages markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase.

[Cell Death & Disease] Analysis showed that PRMT3-mediated tumorigenesis was HIF1α methylation-dependent. A novel therapeutic molecule (MPG-peptide) was used to inhibit HIF1α expression.