colorectal cancer

[Nature Communications] Scientists profiled 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidated the potential origin and regulation of tumor-enriched cell types in colorectal cancer.

[Pharmacological Research] Regulatory T cells (Tregs) are a form of T cells, which regulate and suppress unwanted activation of the immune system and play a major role in preventing autoimmune diseases.

[Acta Pharmacologica Sinica] Alcohol dehydrogenase 1C (ADH1C) was first identified as a target gene closely associated with the development of CRC by the comprehensive application of transcriptomics, proteomics, metabonomics and in silico analysis.

[British Journal of Cancer] The authors revealed new roles for aryl-hydrocarbon receptor-interacting protein in regulating proteins associated with cancer and metastasis to induce tumorigenic and metastatic properties in colon cancer cells driving liver metastasis.

[BMC Cancer] Scientists evaluated the selective inhibition of α-mangostin on CSCs in colorectal cancer and the suppressive effect on 5-fluorouracil-induced CSCs.

[Cell Death & Disease] Scientists detected the receptor tyrosine kinase activity in gefitinib-resistant colorectal cancer cells, pan-erb-b2 receptor tyrosine kinase 3 (ErbB3)/EGFR was significantly activated and provided a potential multi-ErbB treatment target.