colorectal cancer

[Oncology Reports] In vitro, the AZD6738/5‑FU combination increased the number of mitotic cells according to flow cytometry, decreased the checkpoint kinase 1 phosphorylation levels and increased cleaved caspase‑3 and phosphorylated form of H2A.X variant histone levels according to western blotting, and decreased the proliferation rate of four colon cancer cell lines according to cell viability experiments.

[IUBMB Life] Scientists determined the epigenetic features of the HNF1A gene loci, and expression and cellular localization of HNF1A-AS1 RNA, HNF1A RNA, and HNF1A protein in colorectal cancer and normal colon epithelial cells.

[Scientific Reports] The authors determined if mouse hepatic progenitor cells — oval cells (OCs) — were susceptible to incorporate Kras GAT mutation from mouse colorectal cancer cell line CT26.WT and if OCs with the incorporated mutation behaved like malignant cells.

[Journal of Medicinal Chemistry] Researchers described the optimization of the first lead chromodomain helicase DNA-binding protein 1 like inhibitors through drug design and medicinal chemistry.

[Ecotoxicology and Environmental Safety] Researchers described a novel computational method for characterizing toxicity, associated biological perturbations and disease outcome, called the Chemo-Phenotypic Based Toxicity Measurement. The method was validated in the in vitro, in vivo and organoid models.

[Ecotoxicology and Environmental Safety] Researchers described a novel computational method for characterizing toxicity, associated biological perturbations and disease outcome, called the Chemo-Phenotypic Based Toxicity Measurement. The method was validated in the in vitro, in vivo and organoid models.