COVID-19

[Aging-Us] Investigators explore the role of cellular senescence in age-associated lymphoid organ dysfunction and immunosenescence, and provide a framework to explore therapies to rejuvenate the aged immune system.

[Trillium Therapeutics, Inc.] Trillium Therapeutics, Inc. announced that it has dosed the first TP53-mutated acute myeloid leukemia patient with TTI-622, an investigational checkpoint inhibitor of the innate immune system, in combination with azacitidine.

[Blood Cancer Journal] The authors evaluated the safety and immunogenicity of BNT162b2 vaccine in patients with hematological malignancies.

[Cell Discovery] By performing scRNA/V(D)J-seq on peripheral blood mononuclear cells from four COVID-19 vaccine trial participants longitudinally during immunization, investigators revealed enhanced cellular immunity with concerted and cell type-specific IFN responses as well as boosted humoral immunity with SARS-CoV-2-specific antibodies.

[Nature Reviews Immunology] Scientists review evidence that SARS-CoV-2 directly or indirectly activates inflammasomes, leading to secretion of the pleiotropic IL-1 family cytokines and pyroptosis.

[Scientific Reports] Scientists obtained high-throughput gene expression data associated with human lung epithelial cells infected with respiratory viruses such as SARS-CoV-2, SARS, H1N1, avian influenza, rhinovirus and Dhori, then performed comparative transcriptome analysis to identify SARS-CoV-2 exclusive genes.