COVID-19

[Nature Reviews Cardiology] Scientists discuss how the synergy between inflammation and thrombosis drives thrombotic diseases. They focus on the huge potential of anti-inflammatory strategies to target cardiovascular pathologies.

[Clinical Infectious Diseases] Scientists measured the susceptibility to infection, immune response, and expression of adhesion molecules, in human pulmonary microvascular endothelial cells exposed to conditioned medium from infected epithelial cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists found target site duplications flanking the viral sequences and consensus LINE1 endonuclease recognition sequences at the integration sites, consistent with a LINE1 retrotransposon-mediated, target-primed reverse transcription and retroposition mechanism.

[Nature News] In a historic move, the US government has today announced its support for waiving patent protections for COVID-19 vaccines, a measure aimed at boosting supplies so that people around the world can get the shots.

[ScienceInsider] Indian researchers say they urgently need better access to data collected by government agencies to help them understand and fight the country’s devastating second pandemic wave. An open letter published on 29 April that has 740 signatories so far asks the government for access to databases on COVID-19 testing and genomic sequencing and urges it to remove other obstacles to research.

[Journal of Clinical Investigation] Investigators assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients and 38 non-COVID-19 patients, using flow cytometry.