critical limb ischemia

[Scientific Reports] The effects of specific miRNAs on angiogenesis were evaluated by assessing the in vitro angiogenic function of endothelial progenitor cells, performing an in vivo angiogenesis assay, and employing a mouse hindlimb ischemic model.

[Scientific Reports] Researchers evaluated the ability of mast cells and MSCs to induce angiogenesis in a rat model of ischemic hind limb injury on a background of a tissue engineered hydrogel scaffold.

[Journal of the American Heart Association] Critical limb ischemia in type 2 diabetes mouse model was used to explore the impact of diabetic limb ischemia on the survival of bone marrow mesenchymal stromal cells.

[Trials] The authors evaluated the feasibility, safety, and efficacy of cell therapy based on mesenchymal stromal cells derived from adipose tissue intramuscular administration to patients with type 2 diabetes mellitus with critical limb ischemia and without possibility of revascularization.

[npj Regenerative Medicine] Scientists demonstrated that IL-8 was upregulated by the FGF2-mediated priming effect during FECS-Ad formation. Immobilized FGF2 substrate induced stronger IL-8 expression than soluble FGF2 ligands, presumably through the FGFR1/JNK/NF-κB signaling cascade.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators showed that gene-edited, immune-evasive cell grafts could survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. A mixture of endothelial cells and cardiomyocytes was injected into infarcted mouse hearts, and both cell types orthotopically engrafted in the ischemic areas.