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Pulmonary Cell NewsScientists demonstrated that IL-8 was upregulated by the FGF2-mediated priming effect during FECS-Ad formation. Immobilized FGF2 substrate induced stronger IL-8 expression than soluble FGF2 ligands, presumably through the FGFR1/JNK/NF-κB signaling cascade.
[npj Regenerative Medicine]
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Choi, J., Choi, W., Joo, Y., Chung, H., Kim, D., Oh, S. J., & Kim, S.-H. (2021). FGF2-primed 3D spheroids producing IL-8 promote therapeutic angiogenesis in murine hindlimb ischemia. Npj Regenerative Medicine, 6(1), 1–15. https://doi.org/10.1038/s41536-021-00159-7 Cite
