Progress of Gene Therapy in Cardiovascular Disease

Researchers discuss the recent advances in proangiogenic gene therapy for critical limb ischemia and DNA vaccine for hypertension.
[Hypertension]
Shimamura Munehisa, Nakagami Hironori, Sanada Fumihiro, & Morishita Ryuichi. (n.d.). Progress of Gene Therapy in Cardiovascular Disease. Hypertension, 0(0), HYPERTENSIONAHA.120.14478. https://doi.org/10.1161/HYPERTENSIONAHA.120.14478 Cite
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Targeting QKI-7 In Vivo Restores Endothelial Cell Function in Diabete

QKI-7 is highly expressed in human coronary arterial endothelial cells from diabetic donors, and on blood vessels from diabetic critical limb ischemia patients undergoing a lower-limb amputation.
[Nature Communications]
Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M. V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F. L., Lois, N., Stitt, A. W., Grieve, D. J., & Margariti, A. (2020). Targeting QKI-7 in vivo restores endothelial cell function in diabetes. Nature Communications, 11(1), 3812. https://doi.org/10.1038/s41467-020-17468-y Cite
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Temporal Changes Guided by Mesenchymal Stem Cells on a 3D Microgel Platform Enhance Angiogenesis In Vivo at a Low-Cell Dose

Researchers demonstrated the biophysical and biochemical effects of preconditioning human mesenchymal stem cells for 96 hours on a three-dimensional extracellular matrix-based microgel platform.
[Proceedings of the National Academy of Sciences of the United States of America]
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Allogeneic Adipose‐Derived Stem Cells Promote Ischemic Muscle Repair by Inducing M2 Macrophage Polarization via the HIF ‐1α/IL ‐10 Pathway

The transplantation of adipose‐derived mesenchymal stem cells (ASCs) into ischemic limbs induced increased blood flow reperfusion and limb salvage rate, whereas the depletion of tissue macrophages or transplanting HIF‐1α‐silenced ASCs inhibited the therapeutic effect.
[Stem Cells]
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