Hypoimmune Induced Pluripotent Stem Cell–Derived Cell Therapeutics Treat Cardiovascular and Pulmonary Diseases in Immunocompetent Allogeneic Mice

Investigators showed that gene-edited, immune-evasive cell grafts could survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. A mixture of endothelial cells and cardiomyocytes was injected into infarcted mouse hearts, and both cell types orthotopically engrafted in the ischemic areas.