Human Adipose-Derived Stem Cells Enriched with VEGF-Modified mRNA Promote Angiogenesis and Long-Term Graft Survival in a Fat Graft Transplantation Model

Human adipose-derived stem cells were acquired from lipoaspiration and transfected with modRNAs. Transfection efficiency and expression kinetics of modRNAs in hADSCs were first evaluated in vitro.
[Stem Cell Research & Therapy]
Yu, F., Witman, N., Yan, D., Zhang, S., Zhou, M., Yan, Y., Yao, Q., Ding, F., Yan, B., Wang, H., Fu, W., Lu, Y., & Fu, Y. (2020). Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model. Stem Cell Research & Therapy, 11(1), 490. https://doi.org/10.1186/s13287-020-02008-8 Cite
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Paracrine Effect of Human Adipose-Derived Stem Cells on Lymphatic Endothelial Cells

Investigators evaluated, in vitro, the potential paracrine effect of human adipose-derived stem cells to promote lymphangiogenesis in lymphatic endothelial cells isolated from rat diaphragmatic lymphatic vessels.
[Regenerative Medicine]
Marcozzi, C., Frattini, A., Borgese, M., Rossi, F., Barone, L., Solari, E., Valli, R., & Gornati, R. (2020). Paracrine effect of human adipose-derived stem cells on lymphatic endothelial cells. Regenerative Medicine. https://doi.org/10.2217/rme-2020-0071 Cite
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Angiogenic Factors Secreted From Human ASC Spheroids Entrapped in an Alginate-Based Hierarchical Structure via Combined 3D Printing/Electrospinning System

Scientists developed an alginate-based scaffolding structure, which was processed using three-dimensional printing and electrospinning for use as a spheroid-entrapping structure.
[Biofabrication]
Lee, J.-S., Chae, S., Yoon, D., Yoon, D., Chun, W., & Kim, G. H. (2020). Angiogenic factors secreted from human ASC spheroids entrapped in an alginate-based hierarchical structure via combined 3D printing/electrospinning system. Biofabrication. https://doi.org/10.1088/1758-5090/abaf9a Cite
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Adipose Stem Cells and PRP Induce Vascular-Like Structures in a Dermal Regeneration Template

Integra® Dermal Regeneration Template was sprinkled with adipose-derived stem cells in complete medium supplemented with 10% Fetal Bovine Serum, or stromal vascular fraction, obtained from emulsified or non-emulsified fat, in medium supplemented with 2% platelet-rich plasma.
[Tissue Engineering]
Beccia, E., Carbone, A., Cecchino, L. R., Pedicillo, M. C., Annacontini, L., Lembo, F., Di Gioia, S., Parisi, D., Angiolillo, A., Pannone, G., Portincasa, A., & Conese, M. (2020). Adipose stem cells and PRP induce vascular-like structures in a Dermal Regeneration Template. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0175 Cite
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Mannitol Augments the Effects of Systemical Stem Cell Transplantation without Increasing Cell Migration in a Stroke Animal Model

Researchers elucidated the neuroprotective effects of a combination of mannitol pretreatment and stem cell transplantation on stroke-induced neural injury.
[Journal of Tissue Engineering and Regenerative Medicine]
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Adipose-Derived Mesenchymal Stem Cells Promote the Malignant Phenotype of Cervical Cancer

Investigators described for the first time the impact of adipose-derived stem cells over the malignant behavior of cervical cancer cells.
[Scientific Reports]
Castro-Oropeza, R., Vazquez-Santillan, K., Díaz-Gastelum, C., Melendez-Zajgla, J., Zampedri, C., Ferat-Osorio, E., Rodríguez-González, A., Arriaga-Pizano, L., & Maldonado, V. (2020). Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer. Scientific Reports, 10(1), 14205. https://doi.org/10.1038/s41598-020-69907-x Cite
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Aspiration-Assisted Bioprinting of the Osteochondral Interface

Tissue spheroids, made of human adipose-derived stem cells, were differentiated in three dimensions into chondrogenic and osteogenic spheroids, which were confirmed by immunostaining and histology qualitatively, and biochemistry assays and gene expression, quantitatively.
[Scientific Reports]
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Activating PIK3CA Mutation Promotes Adipogenesis of Adipose-Derived Stem Cells in Macrodactyly via Up-Regulation of E2F1

PIK3CA (H1047R) Activating Mutation and Enhanced Activity of PI3K/AKT Pathway were Detected in Macrodactylous Adipose-Derived Stem Cells (Mac-ADSCs).
[Cell Death & Disease]
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Extracellular Vesicle‐Enclosed MiR‐486‐5p Mediates Wound Healing with Adipose‐Derived Stem Cells by Promoting Angiogenesis

Researchers investigated the role of adipose‐derived stem cells‐extracellular vesicles in the cutaneous wound healing accompanied with the study on the specific cargo‐medicated effects on wound healing.
[Journal of Cellular and Molecular Medicine]
Lu, Y., Wen, H., Huang, J., Liao, P., Liao, H., Tu, J., & Zeng, Y. (n.d.). Extracellular vesicle-enclosed miR-486-5p mediates wound healing with adipose-derived stem cells by promoting angiogenesis. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/10.1111/jcmm.15387 Cite
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Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing

This study compared the phenotypes of adipose tissue-derived mesenchymal stem cells harvested from high-fat diet, streptozotocin-induced type 2 diabetes (T2D) and healthy Chow diet-fed C57BL/6 mice in vitro and their therapeutic effects for the treatment of wound healing in a mouse model of T2D.
[Stem Cell Research & Therapy]
Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved July 20, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01817-1 Cite
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Adipose Tissue: A Source of Stem Cells with Potential for Regenerative Therapies for Wound Healing

This review describes the current understanding of the origin, different types, anatomical location, and genetics of adipose tissue as well as discussing the properties of adipose-derived stem cells and their promising applications for tissue engineering, scarring, and wound healing.
[Journal of Clinical Medicine]
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