Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia.
[Current Stem Cell Research & Therapy]
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Transplantation of 3D Adipose-Derived Stem Cell/Hepatocyte Spheroids Alleviates Chronic Hepatic Damage in a Rat Model of Thioacetamide-Induced Liver Cirrhosis

Investigators reported a new approach that enables the formation of self-assembled 3D spheroids of adipose-derived stem cells and murine hepatocytes via reconstituted collagen fibers.
[Scientific Reports]
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Injectable Amnion Hydrogel-Mediated Delivery of Adipose-Derived Stem Cells for Osteoarthritis Treatment

Investigators evaluated the efficacy of intraarticular injections of amnion membrane hydrogels with and without adipose-derived stem cells in reducing inflammation and cartilage degeneration in a collagenase-induced osteoarthritis rat model.
[Proceedings of the National Academy of Sciences of the United States of America]
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An Immunologically Active, Adipose-Derived Extracellular Matrix Biomaterial for Soft Tissue Reconstruction: Concept to Clinical Trial

Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.
[NPJ Regenerative Medicine]
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The Synthetic Artificial Stem Cell (SASC): Shifting the Paradigm of Cell Therapy in Regenerative Engineering

Scientists engineered a SASC system which mimicked the paracrine effect of the stem cell secretome and provided tailorability of the composition for targeted tissue regeneration.
[Proceedings of the National Academy of Sciences of the United States of America]
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Sanford Health Opens Stem Cell Trial for Arthritis Patients

Sanford Health announced a stem cell trial expanding the use of adult-adipose derived stem cells in the use of osteoarthritis across five joints. The clinical trial, called the ENDURE trial, is the first of its kind study.
[Stanford Health]
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α1-Adrenergic Receptor Mediates Adipose-Derived Stem Cell Sheet-Induced Protection against Chronic Heart Failure after Myocardial Infarction in Rats

Hypoxia increased α1-AR and vascular endothelial growth factor (VEGF) mRNA levels in adipose-derived stem cells. Norepinephrine further increased VEGF mRNA expression under hypoxia; this effect was abolished by doxazosin.
[Hypertension Research]
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Protective Effects of Low-Molecular-Weight Components of Adipose Stem Cell-Derived Conditioned Medium on Dry Eye Syndrome in Mice

Researchers demonstrated the protective effects of low-molecular-weight adipose-derived stem cell-conditioned medium in a mouse model of dry eye syndrome.
[Scientific Reports]
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miR-20a Overexpression in Adipose-Derived Mesenchymal Stem Cells Promotes Therapeutic Efficacy in Murine Lupus Nephritis by Regulating Autophagy

Scientists investigated the efficacy of miR-20a overexpressing adipose-derived stem cell transplantation in murine lupus nephritis and explored potential molecular mechanisms.
[Stem Cells International]
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Insight into the Role of Dermal White Adipose Tissue Loss in Dermal Fibrosis

The authors indicate that the adipocytes-to-myofibroblasts transition in dermal white adipose tissue reflects the direct contribution to the dermal fibrosis formation
[Journal of Cellular Physiology]
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Adipose-Derived Stem Cells Inhibit Dermal Fibroblast Growth and Induce Apoptosis in Keloids through the Arachidonic Acid-Derived Cyclooxygenase-2/Prostaglandin E2 Cascade by Paracrine

Scientists found out how the conditioned medium of adipose-derived stem cells exerted an anti-fibrotic effect in keloid dermis-derived fibroblasts.
[Burns & Trauma]
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