Human adipose-derived stem cells were acquired from lipoaspiration and transfected with modRNAs. Transfection efficiency and expression kinetics of modRNAs in hADSCs were first evaluated in vitro.
[Stem Cell Research & Therapy]
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Yu, F., Witman, N., Yan, D., Zhang, S., Zhou, M., Yan, Y., Yao, Q., Ding, F., Yan, B., Wang, H., Fu, W., Lu, Y., & Fu, Y. (2020). Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model. Stem Cell Research & Therapy, 11(1), 490. https://doi.org/10.1186/s13287-020-02008-8 Cite
Investigators evaluated, in vitro, the potential paracrine effect of human adipose-derived stem cells to promote lymphangiogenesis in lymphatic endothelial cells isolated from rat diaphragmatic lymphatic vessels.
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Scientists developed an alginate-based scaffolding structure, which was processed using three-dimensional printing and electrospinning for use as a spheroid-entrapping structure.
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Integra® Dermal Regeneration Template was sprinkled with adipose-derived stem cells in complete medium supplemented with 10% Fetal Bovine Serum, or stromal vascular fraction, obtained from emulsified or non-emulsified fat, in medium supplemented with 2% platelet-rich plasma.
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Beccia, E., Carbone, A., Cecchino, L. R., Pedicillo, M. C., Annacontini, L., Lembo, F., Di Gioia, S., Parisi, D., Angiolillo, A., Pannone, G., Portincasa, A., & Conese, M. (2020). Adipose stem cells and PRP induce vascular-like structures in a Dermal Regeneration Template. Tissue Engineering Part A. https://doi.org/10.1089/ten.TEA.2020.0175 Cite
Researchers elucidated the neuroprotective effects of a combination of mannitol pretreatment and stem cell transplantation on stroke-induced neural injury.
[Journal of Tissue Engineering and Regenerative Medicine]
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Investigators described for the first time the impact of adipose-derived stem cells over the malignant behavior of cervical cancer cells.
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Castro-Oropeza, R., Vazquez-Santillan, K., Díaz-Gastelum, C., Melendez-Zajgla, J., Zampedri, C., Ferat-Osorio, E., Rodríguez-González, A., Arriaga-Pizano, L., & Maldonado, V. (2020). Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer. Scientific Reports, 10(1), 14205. https://doi.org/10.1038/s41598-020-69907-x Cite
Tissue spheroids, made of human adipose-derived stem cells, were differentiated in three dimensions into chondrogenic and osteogenic spheroids, which were confirmed by immunostaining and histology qualitatively, and biochemistry assays and gene expression, quantitatively.
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PIK3CA (H1047R) Activating Mutation and Enhanced Activity of PI3K/AKT Pathway were Detected in Macrodactylous Adipose-Derived Stem Cells (Mac-ADSCs).
[Cell Death & Disease]
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Researchers investigated the role of adipose‐derived stem cells‐extracellular vesicles in the cutaneous wound healing accompanied with the study on the specific cargo‐medicated effects on wound healing.
[Journal of Cellular and Molecular Medicine]
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This study compared the phenotypes of adipose tissue-derived mesenchymal stem cells harvested from high-fat diet, streptozotocin-induced type 2 diabetes (T2D) and healthy Chow diet-fed C57BL/6 mice in vitro and their therapeutic effects for the treatment of wound healing in a mouse model of T2D.
[Stem Cell Research & Therapy]
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Adipose stem cells from type 2 diabetic mice exhibit therapeutic potential in wound healing | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved July 20, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01817-1 Cite
This review describes the current understanding of the origin, different types, anatomical location, and genetics of adipose tissue as well as discussing the properties of adipose-derived stem cells and their promising applications for tissue engineering, scarring, and wound healing.
[Journal of Clinical Medicine]
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