cyclin D1

[Cardiovascular Research] Both pharmacological focal adhesion kinase (FAK) and genetic FAK inhibition reduced S-phase kinase-associated protein 2 (Skp2) expression in Vascular smooth muscle cells (VSMCs) upon injury, which significantly reduced intimal hyperplasia through elevated expression of p27 and p21.

[Oncogene] Both immunohistochemistry and Western blot assays demonstrated that the expression of PR domain zinc finger protein 4 (PRDM4) in cervical cancer tissues was much lower than that in the normal cervix.

[Cell Death & Disease] Investigators showed that monocyte chemotactic protein induced protein 1 (MCPIP1) was downregulated in 80 TNBC tissues and five TNBC cell lines compared to adjacent paracancerous tissues and one human immortalized breast epithelial cell line, while its high expression levels were associated with increased overall survival in TNBC patients.

[Stem Cell Research & Therapy] 24 miniature pigs were subjected to laparoscopic liver ischemia-reperfusion combined with partial hepatectomy and divided into the following four groups: the saline group, the DMEM group, the adipose-derived MSC (ASC) group and the ASC-secretome group.

[Cell Death Discovery] Gain- or loss-of-function assays demonstrated that miR-23b-5p induced G0/G1 cell cycle arrest and inhibited cell proliferation both in vitro and in vivo. qRT-PCR, western blot and luciferase assays verified that Mammalian transcription factor Forkhead Box M1 (FOXM1), upregulated in hepatocellular carcinoma specimens, was negatively correlated with miR-23b-5p expression and acted as a direct downstream target of miR-23b-5p.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Scientists investigated the effect of Gli2 on liver fibrogenesis and its possible mechanism using conditional knockout Gli2 mice and hepatic stellate cell models.