dendritic cells

[Scientific Reports] An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to control subjects, postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and blood culture-positive patients.

[Immunity] Researchers examined how the cholesterol metabolite 25-hydroxycholesterol impacted the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase, the enzyme generating 25-HC, had higher frequencies of immunoglobulin A-secreting antigen-specific B cells upon immunization or infection.

[Immunity] Researchers examined how targeting pathways that inhibit the differentiation of inflammatory myeloid cells affect antitumor immunity.

[Journal of Immunology] The authors showed that direct fusion of CD40L to certain agonistic anti-CD40 Abs conferred superagonist properties, reducing the dose required for efficacy, notably greatly increasing total cytokine secretion by human dendritic cells.

[Scientific Reports] Scientists showed that systemic delivery of tumor-associated antigens facilitated in vivo priming and expansion of previously non-activated T cells and enhanced the cytotoxicity of activated T cells.

[Cancer Medicine] SEC61G expression was analyzed using publicly available datasets. The association between SEC61G and disease prognosis was evaluated.