dendritic cells

[Immunity] Scientists examined the contribution of interleukin (IL)-4 on B cell fate decisions in the GC. Single-cell RNA-sequencing identified a subset of light zone GC B cells expressing high IL-4 receptor-a and CD23 and lacking a Myc-associated signature.

[Cell Reports] Restoration of the gut bile acids pool attenuated severity of experimental autoimmune uveitis in association with inhibition of nuclear factor κB related pro-inflammatory cytokines in dendritic cells.

[Nature Reviews Immunology] The authors highlight emerging functions of oxidized phosphocholines in dendritic cells and macrophages that drive unique inflammasome and migratory activities and hypermetabolic states.

[Journal of Hematology & Oncology] The synergistic effect between Bivalent manganese and YM101 in vitro was determined by one-way mixed lymphocyte reaction, CFSE dilution assay, and cytokine detection.

[Immunity] In tumors, a subset of CD8+ T cells expressing the transcription factor TCF-1 drives the response to immune checkpoint blockade. Scientists examined the mechanisms that maintain these cells in an autochthonous model of lung adenocarcinoma.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified the cell-surface–expressed A-disintegrin-and-metalloproteinase 10 as an essential regulator of conventional dendritic cell (cDC)1 and cDC2 homeostasis in the splenic marginal zone.