Combine and Conquer: Manganese Synergizing Anti-TGF-β/PD-L1 Bispecific Antibody YM101 to Overcome Immunotherapy Resistance in Non-Inflamed Cancers

The synergistic effect between Bivalent manganese and YM101 in vitro was determined by one-way mixed lymphocyte reaction, CFSE dilution assay, and cytokine detection.