Neoantigen-Reactive CD8+ T Cells Affect Clinical Outcome of Adoptive Transfer with Tumor-Infiltrating Lymphocytes in Melanoma

Using barcoded pMHC multimers, scientists provided a comprehensive mapping of CD8+ T cells recognizing neoepitopes in Tumor-Infiltrating Lymphocyte infusion products and blood samples from 26 metastatic mela-noma patients who received adoptive cell therapy.
[Journal of Clinical Investigation]
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Fusobacterium nucleatum Enhances the Efficacy of PD-L1 Blockade in Colorectal Cancer

Fusobacterium nucleatum induces different immune responses in colorectal cancer (CRC) with different microsatellite-instability statuses. Scientists investigated the effect of F. nucleatum on anti-PD-L1 therapy in CRC.
[Signal Transduction and Targeted Therapy]
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Autotaxin Impedes Anti-Tumor Immunity by Suppressing Chemotaxis and Tumor Infiltration of CD8+ T Cells

Investigators showed that autotaxin (ATC) secreted by melanoma cells was chemorepulsive for tumor-infiltrating lymphocytes and circulating CD8+ T cells ex vivo, with autotaxin functioning as an LPA-producing chaperone.
[Cell Reports]
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Proteasome Inhibitors Restore the STAT1 Pathway and Enhance the Expression of MHC Class I on Human Colon Cancer Cells

Scientists applied three colon cancer cell lines, including microsatellite stable cell lines, which are SW480 and SW620, and microsatellite instability-high cell line, which is DLD-1.
[Journal of Biomedical Science]
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Myeloid Antigen-Presenting Cell Niches Sustain Antitumor T Cells and License PD-1 Blockade via CD28 Costimulation

Investigators showed that tumor-specific CD8+ tumor-infiltrating lymphocytes accumulated in tumor islets, where they engage antigen and upregulate PD-1, which restrained their functions.
[Cancer Cell]
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Breast Cancer Immune Microenvironment: From Pre-Clinical Models to Clinical Therapies

The authors examine the role of immune-activating cells, including tumour-infiltrating lymphocytes, and natural killer cells, as well as immune inhibitory cells, including T regulatory cells, and myeloid-derived suppressor cells in the breast cancer tumour microenvironment.
[Breast Cancer Research and Treatment]
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Dysregulation of TFH-B-TRM Lymphocyte Cooperation Is Associated with Unfavorable Anti-PD-1 Responses in EGFR-Mutant Lung Cancer

Hypothesizing that EGFR mutations alter tumor-immune interactions, scientists compared tumor-infiltrating lymphocytes between EGFR mutant and wild type tumors through single-cell transcriptomic analysis.
[Nature Communications]
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Adoptive CD8+T-Cell Grafted with Liposomal Immunotherapy Drugs to Counteract the Immune Suppressive Tumor Microenvironment and Enhance Therapy for Melanoma

The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. Effector OT-1 CD8+T cells conjugated with liposomal immune regulators were developed to address this issue.
[Nanoscale]
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Oestrogen Deprivation Induces Chemokine Production and Immune Cell Recruitment in In Vitro and In Vivo Models of Oestrogen Receptor-Positive Breast Cancer

Scientists investigated the effect of oestrogen deprivation on the expression of chemokines and immune infiltration in vitro and in an ER+ immunocompetent mouse model.
[Breast Cancer Research]
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Identification of Immune-Related Subtypes of Colorectal Cancer to Improve Antitumor Immunotherapy

42.8% of patients who exhibited significantly higher immunocyte infiltration and enrichment of immune response-associated signatures were subdivided into immune classes.
[Scientific Reports]
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Combine and Conquer: Manganese Synergizing Anti-TGF-β/PD-L1 Bispecific Antibody YM101 to Overcome Immunotherapy Resistance in Non-Inflamed Cancers

The synergistic effect between Bivalent manganese and YM101 in vitro was determined by one-way mixed lymphocyte reaction, CFSE dilution assay, and cytokine detection.
[Journal of Hematology & Oncology]
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