PD-1 Suppresses the Maintenance of Cell Couples between Cytotoxic T Cells and Target Tumor Cells within the Tumor

To find cellular defects triggered by tumor exposure and associated PD-1 signaling, scientists established an ex vivo imaging approach to investigate the response of antigen-specific, activated effector CD8+ tumor-infiltrating lymphocytes after interaction with target tumor cells.
[Science Signaling]
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Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

Investigators identified a gradient of increasing glucocorticoid receptor expression and signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes.
[Immunity]
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Prognostic Value of Tertiary Lymphoid Structure and Tumor Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Associated markers of tertiary lymphoid structures (TLS), including peripheral node address in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 oral squamous cell carcinoma patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts.
[International Journal of Oral Science]
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Dysfunction of CD8+ PD-1+ T Cells in Type 2 Diabetes Caused by the Impairment of Metabolism-Immune Axis

In CD8+ splenic T cells from the HFS mice, glycolysis/basal respiration ratio was significantly reduced and reversed by metformin.
[Scientific Reports]
Nojima, I., Eikawa, S., Tomonobu, N., Hada, Y., Kajitani, N., Teshigawara, S., Miyamoto, S., Tone, A., Uchida, H. A., Nakatsuka, A., Eguchi, J., Shikata, K., Udono, H., & Wada, J. (2020). Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis. Scientific Reports, 10(1), 14928. https://doi.org/10.1038/s41598-020-71946-3 Cite
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Visualization of Human T Lymphocyte-Mediated Eradication of Cancer Cells In Vivo

The authors report a living zebrafish model that allowed the visualization the metastatic cancer cell killing effect by tumor- infiltrating lymphocytes (TILs) and CAR-T cells in vivo at the single-cell level. In a freshly isolated primary human melanoma, specific TILs effectively eliminated metastatic cancer cells in the living body.
[Proceedings of the National Academy of Sciences of the United States of America]
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Tumoral and Paratumoral NK Cells and CD8+ T Cells of Esophageal Carcinoma Patients Express High Levels of CD47

A total of 36 tissue samples from tumors, peritumoral tissue, and adjacent healthy esophageal tissue was obtained from 12 esophageal carcinoma patients, and the surface expression of CD47 was evaluated in NK cells, CD8+ T cells, and the nonlymphocyte cell fraction.
[Scientific Reports]
Strizova, Z., Vachtenheim, J., Snajdauf, M., Lischke, R., Bartunkova, J., & Smrz, D. (2020). Tumoral and paratumoral NK cells and CD8 + T cells of esophageal carcinoma patients express high levels of CD47. Scientific Reports, 10(1), 13936. https://doi.org/10.1038/s41598-020-70771-y Cite
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EPHA5 Mutation Predicts the Durable Clinical Benefit of Immune Checkpoint Inhibitors in Patients with Lung Adenocarcinoma

Scientists report that Eph receptor A5 (EPHA5) mutations were associated with increased tumor mutation burden, neoantigen load, levels of immune-related gene expression signatures, and enhanced tumor-infiltrating lymphocytes in lung adenocarcinoma.
[Cancer Gene Therapy]
Huang, W., Lin, A., Luo, P., Liu, Y., Xu, W., Zhu, W., Wei, T., Lyu, Q., Guo, L., & Zhang, J. (2020). EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma. Cancer Gene Therapy, 1–11. https://doi.org/10.1038/s41417-020-0207-6 Cite
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Oncolytic Virus Promotes Tumor-Reactive Infiltrating Lymphocytes for Adoptive Cell Therapy

The authors showed that a local injection of oncolytic poxvirus in MC38 tumor with low immunogenicity in C57BL/6 mice, led to elicitation and accumulation of tumor-specific tumor-infiltrating lymphocytes in the tumor tissue.
[Cancer Gene Therapy]
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