To find cellular defects triggered by tumor exposure and associated PD-1 signaling, scientists established an ex vivo imaging approach to investigate the response of antigen-specific, activated effector CD8+ tumor-infiltrating lymphocytes after interaction with target tumor cells.
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Investigators identified a gradient of increasing glucocorticoid receptor expression and signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes.
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Associated markers of tertiary lymphoid structures (TLS), including peripheral node address in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 oral squamous cell carcinoma patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts.
[International Journal of Oral Science]
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In CD8+ splenic T cells from the HFS mice, glycolysis/basal respiration ratio was significantly reduced and reversed by metformin.
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Nojima, I., Eikawa, S., Tomonobu, N., Hada, Y., Kajitani, N., Teshigawara, S., Miyamoto, S., Tone, A., Uchida, H. A., Nakatsuka, A., Eguchi, J., Shikata, K., Udono, H., & Wada, J. (2020). Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis. Scientific Reports, 10(1), 14928. https://doi.org/10.1038/s41598-020-71946-3 Cite
The authors report a living zebrafish model that allowed the visualization the metastatic cancer cell killing effect by tumor- infiltrating lymphocytes (TILs) and CAR-T cells in vivo at the single-cell level. In a freshly isolated primary human melanoma, specific TILs effectively eliminated metastatic cancer cells in the living body.
[Proceedings of the National Academy of Sciences of the United States of America]
A total of 36 tissue samples from tumors, peritumoral tissue, and adjacent healthy esophageal tissue was obtained from 12 esophageal carcinoma patients, and the surface expression of CD47 was evaluated in NK cells, CD8+ T cells, and the nonlymphocyte cell fraction.
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Scientists report that Eph receptor A5 (EPHA5) mutations were associated with increased tumor mutation burden, neoantigen load, levels of immune-related gene expression signatures, and enhanced tumor-infiltrating lymphocytes in lung adenocarcinoma.
[Cancer Gene Therapy]
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The authors showed that a local injection of oncolytic poxvirus in MC38 tumor with low immunogenicity in C57BL/6 mice, led to elicitation and accumulation of tumor-specific tumor-infiltrating lymphocytes in the tumor tissue.
[Cancer Gene Therapy]
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