T-Regulatory Cells Predict Clinical Outcome in Soft Tissue Sarcoma Patients: A Clinico-Pathological Study

Investigators analyzed tumor-infiltrating lymphocytes and immune checkpoint molecules in soft tissue sarcomas, and assessed their prognostic impact regarding local recurrence, distant metastasis, and overall survival.
[British Journal of Cancer]
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Assessment of Copy Number in Protooncogenes Are Predictive of Poor Survival in Advanced Gastric Cancer

Researchers characterized the clinicopathological features, including prognosis, of gastric carcinomas with copy number gains in multiple protooncogenes.
[Scientific Reports]
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The Therapeutic Potential of Multiclonal Tumoricidal T Cells Derived from Tumor Infiltrating Lymphocyte-1 derived iPS Cells

Researchers established tumor-specific tumor-infiltrating lymphocytes (TIL)-derived iPS cells with human colorectal cancer specimens to confirm their hypothesis that the anti-tumor effect could be enhanced by TIL regeneration.
[Communications Biology]
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Weighting Tumor-Specific TCR Repertoires as a Classifier to Stratify the Immunotherapy Delivery in Non–small Cell Lung Cancers

REsearchers developed a previously unidentified index, the T cell receptor (TCR)-based immunotherapy response index (TIR index), that estimated the degree of overlap of the TCR repertoire between tumor-infiltrating lymphocytes and circulating PD-1+CD8+T cells
[Science Advances]
Han, J., Yu, R., Duan, J., Li, J., Zhao, W., Feng, G., Bai, H., Wang, Y., Zhang, X., Wan, R., Xu, J., Wang, X., Guan, Y., Xia, X., Yao, Z., Fei, K., Carbone, D. P., Wang, Z., & Wang, J. (2021). Weighting tumor-specific TCR repertoires as a classifier to stratify the immunotherapy delivery in non–small cell lung cancers. Science Advances, 7(21), eabd6971. https://doi.org/10.1126/sciadv.abd6971 Cite
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Liver Fibrosis Promotes Immune Escape in Hepatocellular Carcinoma via GOLM1-Mediated PD-L1 Upregulation

In hepatocellular carcinoma patients, low FIB-4 values and high CD8+ T cell infiltration were correlated with prolonged survival.
[Cancer Letters]
Ke, M., Xu, T., Fang, Y., Ye, Y., Li, Z., Ren, F., Lu, S., Zhang, X., Wu, R., Lv, Y., & Dong, J. (2021). Liver fibrosis promotes immune escape in hepatocellular carcinoma via GOLM1-mediated PD-L1 upregulation. Cancer Letters. https://doi.org/10.1016/j.canlet.2021.05.007 Cite
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Epigenetic Reprogramming of Tumor Cell–Intrinsic STING Function Sculpts Antigenicity and T Cell Recognition of Melanoma

Scientists showed that promoter hypermethylation of cGAS and stimulator of interferon genes (STING) mediated their coordinated transcriptional silencing and contributed to the widespread impairment of the STING signaling function in clinically-relevant human melanomas and melanoma cell lines.
[Proceedings of the National Academy of Sciences of the United States of America]
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Promises and Challenges of Adoptive T-cell Therapies for Solid Tumors

Advances are being made in cell-manufacturing approaches that have the potential to establish cell-therapies as credible therapeutic options. T-cell therapies face many challenges but hold great promise for improving clinical outcomes for patients with solid tumours.
[British Journal of Cancer]
Morotti, M., Albukhari, A., Alsaadi, A., Artibani, M., Brenton, J. D., Curbishley, S. M., Dong, T., Dustin, M. L., Hu, Z., McGranahan, N., Miller, M. L., Santana-Gonzalez, L., Seymour, L. W., Shi, T., Van Loo, P., Yau, C., White, H., Wietek, N., Church, D. N., … Ahmed, A. A. (2021). Promises and challenges of adoptive T-cell therapies for solid tumours. British Journal of Cancer, 1–18. https://doi.org/10.1038/s41416-021-01353-6 Cite
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Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T Cell Effector Functions

Scientists showed that in humans, SLAMF6 has three splice isoforms involving its V-domain. Although the canonical receptor inhibited T-cell activation through SAP recruitment, the short isoform SLAMF6∆17-65 had a strong agonistic effect. T
[Cancer Immunology Research]
Hajaj, E., Zisman, E., Tzaban, S., Merims, S., Cohen, J., Klein, S., Frankenburg, S., Sade-Feldman, M., Tabach, Y., Yizhak, K., Navon, A., Stepensky, P., Hacohen, N., Peretz, T., Veillette, A., Karni, R., Eisenberg, G., & Lotem, M. (2021). Alternative splicing of the inhibitory immune checkpoint receptor SLAMF6 generates a dominant positive form, boosting T cell effector functions. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0800 Cite
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Oleandrin, a Cardiac Glycoside, Induces Immunogenic Cell Death via the PERK/elF2α/ATF4/CHOP Pathway in Breast Cancer

Researchers showed that oleandrin treatment triggered breast cancer cell immunogenic cell death by inducing calreticulin exposure on cell surface and the release of high-mobility group protein B1, heat shock protein 70/90, and adenosine triphosphate.
[Cell Death & Disease]
Li, X., Zheng, J., Chen, S., Meng, F., Ning, J., & Sun, S. (2021). Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03605-y Cite
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HER2-Targeted Antibody-Drug Conjugate Induces Host Immunity against Cancer Stem Cells

The authors tested HER2-targeted antibody-drug conjugates in two immunocompetent mouse tumor models.
[Cell Chemical Biology]
Xia, L., Wen, L., Qin, Y., Dobson, H. E., Zhang, T., Comer, F. I., Hinrichs, M. J., Oberst, M. D., Coats, S. R., Chang, A. E., Liu, Y., Bao, Y., Dai, F., Wicha, M. S., & Li, Q. (2021). HER2-targeted antibody-drug conjugate induces host immunity against cancer stem cells. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2021.02.013 Cite
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A Burned-Out CD8+ T-cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

Using a humanized patient-derived tumor xenograft model, scientists demonstrated that a burned-out CD8+ tumor infiltrating lymphocytes subset expansion occurred within the tumor microenvironment.
[Cancer Discovery]
Sanmamed, M. F., Nie, X., Desai, S. S., Villaroel-Espindola, F., Badri, T., Zhao, D., Kim, A. W., Ji, L., Zhang, T., Quinlan, E., Cheng, X., Han, X., Vesely, M. D., Nassar, A. F., Sun, J., Zhang, Y., Kim, T. K., Wang, J., Melero, I., … Chen, L. (2021). A burned-out CD8+ T-cell subset expands in the tumor microenvironment and curbs cancer immunotherapy. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0962 Cite
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