Tag results:
dendritic cells
Human Immunology News
CD40 Stimulation as a Molecular Adjuvant for Cancer Vaccines and Other Immunotherapies
[Cellular & Molecular Immunology] The rationale and early immunobiology of CD40 as a master regulator of dendritic cell activation is reviewed, with further contextualization and appreciation for the role of CD40 stimulation not only in cancer vaccines but also in other contemporary immune-oncology approaches.
Dermal Cell News
Growth Arrest and DNA Damage-Inducible Proteins (GADD45) in Psoriasis
[Scientific Reports] Researchers analyzed the expression of GADD45a and GADD45b in the skin, dendritic cells and circulating T cells in a cohort of psoriasis patients and their regulation by inflammatory signals.
Immune Regulation News
Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity
[Cancer Research] Investigators showed that inhibition of the hyperactive mevalonate (MVA) metabolic pathway in tumor cells elicited type 1 classical dendritic cells-mediated tumor recognition and antigen cross-presentation for antitumor immunity.
Immune Regulation News
Interferon-α-Producing Plasmacytoid Dendritic Cells Drive the Loss of Adipose Tissue Regulatory T Cells during Obesity
[Cell Metabolism] Researchers exploited the power of a visceral adipose tissue (VAT)-Treg TCR-transgenic mouse model to follow the dynamics of, and phenotypic changes in, the VAT-Treg population throughout the development of diet-induced obesity.
Immunology of Infectious Disease News
Human Immunodeficiency Virus and Human Cytomegalovirus Coinfection of Infant Tonsil Epithelium May Synergistically Promote Both HIV-1 and HCMV Spread and Infection
[Journal of Virology] Scientists showed that cell-free HIV-1 and its proteins gp120 and tat induce the disruption of tonsil epithelial tight junctions and increase paracellular permeability, which facilitates HCMV spread within the tonsil mucosa.
Immune Regulation News
Inflammation and Tumor Progression: Signaling Pathways and Targeted Intervention
[Signal Transduction and Targeted Therapy] Scientists discuss the initiation and resolution of inflammation, the crosstalk between tumor development and inflammatory processes.