dendritic cells

[Scientific Reports] The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.

[Clinical Cancer Research] Researchers used single cell RNA-Seq to define the immune landscape of MBM, LMM and melanoma skin metastases. Single cell RNA-sequencing was undertaken on 43 patient specimens.

[Science Translational Medicine] To evaluate the potential benefit of depleting plasmacytoid dendritic cells (pDCs) in autoimmunity, a monoclonal antibody targeting the pDC-specific marker immunoglobulin-like transcript 7 was generated.

[Journal of Immunology] Investigators hypothesized that bacterial/fungal pathogens triggering RALDH activity in dendritic cells fueled HIV reservoir establishment/outgrowth in pathogen-reactive CD4+ T cells.

[Seminars in Immunopathology] Researchers shed light on potential processes driving the plasticity and heterogeneity of granulocyte subsets and discuss the hematopoietic flexibility of granulocyte precursors in bone marrow and the adaptation of myeloid cells to local tissue microenvironments.

[Nature Medicine] Researchers identified a significant pathology-associated increase in hepatic conventional dendritic cells (cDC) and further defined their source as non-alcoholic fatty liver disease-induced boost in cycling of cDC progenitors in the bone marrow.